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Human Experimentation - Ton J. Cleophas - Bog - Springer - Plusbog.dk

Human Experimentation - Ton J. Cleophas - Bog - Springer - Plusbog.dk

Despite their effectiveness in the evaluation of new pharmacological compounds, controlled clinical trials are sometimes inadequate. Using data from the literature as well as from the author''s own experience with clinical trials, Human Experimentation: Methodologic Issues Fundamental to Clinical Trials addresses such inadequacies and tries to provide solutions. This work is the first to thoroughly examine these unsolved inadequacies and problems with the design and the execution of clinical trials and, more importantly, to provide solutions for these problems. It is important for anyone who is involved in clinical research: clinicians, pharmacists, biochemists, statisticians, nurses, sponsors, etc., and anyone who is involved in applying results of research to patients, i.e. physicians.

DKK 434.00
1

Advances in Ultrasound Technology for Environmental Remediation - Jacqueline Xiao Wen Hay - Bog - Springer - Plusbog.dk

Advances in Ultrasound Technology for Environmental Remediation - Jacqueline Xiao Wen Hay - Bog - Springer - Plusbog.dk

Over the past ten years, innovative technologies have shown that advanced oxidation processes are highly promising when applied to the remediation of polluted water or wastewater as they don''t generate any sludge or solid material of hazardous nature. Advances in Ultrasound Technology for Environmental Remediation reviews the fundamentals of ultrasound technology and the state of the art developments in "ultrasound-based free radical generation" in environmental remediation and pollution prevention. It also presents the challenges of introducing ultrasound technology into large-scale environmental remediation applications and examines the methods used to improve ultrasound technology. Indeed, ultrasonic systems are extremely sensitive and vulnerable to operational parameters which cannot be controlled without a good knowledge and understanding of physical and chemical phenomena. Advances in Ultrasound Technology for Environmental Remediation features the theory and fundamentals of ultrasound technology and discusses its potential as an alternative method in environmental remediation.

DKK 426.00
1

Enzymatic polymerization of phenolic compounds by oxidoreductases - Latifa Chebil - Bog - Springer - Plusbog.dk

Enzymatic polymerization of phenolic compounds by oxidoreductases - Latifa Chebil - Bog - Springer - Plusbog.dk

The enzymatic polymerization of phenolic compounds has been generating interest in several fields such as food, cosmetics, and pharmaceuticals. These compounds are employed for their antioxidant properties; however, their use is limited by their low solubility and thermal stability. Polymerization can improve their solubility and their thermal stability though and create new properties which are dependent on the molecular mass and the structure of polymers. The reaction yield, the polydispersity, the molecular mass, the structure and the properties of synthesized polymers can be controlled by the mode of control of the reaction and by the reaction conditions. Enzymatic polymerization of phenolic compounds by oxidoreductases analyze the processes used and the key factors (temperature, solvent, origin of the enzyme, structure of the substrate, reactor design, ...) which control the polymerization of phenolic species by these oxidoreductase enzymes in order to obtain polymers with desired characteristics and properties.

DKK 426.00
1

Multisensory in Stationary Retail - - Bog - Springer - Plusbog.dk

Multisensory in Stationary Retail - - Bog - Springer - Plusbog.dk

This book describes how an optimal store design can contribute to the well-being of the customer and to differentiation from online retail. From an academic and practical perspective, with contributions from renowned academics and companies, it shows how a coherent store design can be created in harmony with the retail brand. The central challenge here is the conscious orchestration of the diverse sensory stimuli. How can the many sources of stimuli be controlled? Which shelf shape goes with which light, colour and sound? Dealing with the variety of stimuli in a store environment can quickly become complex and incongruence can have a decisive negative impact on the well-being of customers. A customer-centric store environment therefore focuses on the well-being of people. Renowned scientists and traders show the state of the science on these issues and give valuable suggestions for the trade. With best practice examples and valuable suggestions for practical implementation

DKK 604.00
1

Male Fertility and Its Regulation - T.j. Lobl - Bog - Springer - Plusbog.dk

Male Fertility and Its Regulation - T.j. Lobl - Bog - Springer - Plusbog.dk

Uncontrolled population growth, a significant problem for many countries, depresses real living standards in all developing areas. As a corollary, un­ controlled population growth also stresses the ability to deliver adequate reproductive health care on both national and individual levels. To focus on this and related problems an International Congress to examine many aspects of male and female Reproductive Health Center Care was held on 10-15 October 1982 in Maui, Hawaii, USA. This volume is a result of the proceedings from the ''Symposium on Male Fertility and its Regulation'' which was a part of the Reproductive Health Care Congress. The organizers of this symposium recognized the need to focus male reproductive understanding on contraceptive development. The ultimate objective was and still is to produce a variety of safe and effective male contraceptives similar to that accomplished in the female. Speakers were invited to review the state of the art in several areas related to male contra­ ception, reproductive toxicity and reproductive biology. The abstracts of these sessions were published as a special issue of Archives of Andrology (Vol. 9, No.1, August, 1982). Subsequently, this volume was assembled from key papers presented at the Symposium. Additionally, invited man­ uscripts from leaders in specific areas were solicited to provide additional range to the topics covered.

DKK 434.00
1

Physiological Ecology of North American Plant Communities - - Bog - Springer - Plusbog.dk

Physiological Ecology of North American Plant Communities - - Bog - Springer - Plusbog.dk

Although, as W.D. Billings notes in his chapter in this book. the development of physiological ecology can be traced back to the very beginnings of the study of ecology it is clear that the modern development of this field in North America is due in the large part to the efforts of Billings alone. The foundation that Billings laid in the late 1950s came from his own studies on deserts and subsequently arctic and alpine plants, and also from his enormous success in instilling enthusiasm for the field in the numerous students attracted to the plant ecology program at Duke University. Billings'' own studies provided the model for subsequent work in this field. Physiological techniques. normally confined to the laboratory. were brought into the field to examine processes under natural environmental conditions. These field studies were accompanied by experiments under controlled conditions where the relative impact of various factors could be assessed and further where genetic as opposed to environmental influences could be separated. This blending of field and laboratory approaches promoted the design of experiments which were of direct relevance to understanding the distribution and abundance of plants in nature. Physiological mechanisms were studied and assessed in the context of the functioning of plants under natural conditions rather than as an end in itself.

DKK 663.00
1

The Dynamic Body Tissues - W.s. Bullough - Bog - Springer - Plusbog.dk

The Dynamic Body Tissues - W.s. Bullough - Bog - Springer - Plusbog.dk

The study of life is the study of tier upon tier of interlocking homeostatic mechanisms, and the main theme of this book concerns that part of the system that ensures cellular and tissue homeostasis and thus maintains tissue mass, tissue structure and tissue function in the adult mammal. The functional existence of any adult tissue depends on the continuing control of the states of differentiation of its cells. Just as in an embryo, where cellular differentiation is initiated and controlled by the genetic responses of the cells to specific messenger molecules, so also throughout the whole of adult life does the genetic activity of the tissue cells continue to be regulated by similarly specific messenger molecules. The process of differentiation does not cease in the embryo but remains as the essential factor which ensures not only the function but also the continuing existence of the adult tissues. Thus the first problem considered here, the methods of control of cell production, cell function and cell death, is discussed in terms of the nature and mode of action of those messenger molecules which, from moment to moment, determine the states of differentiation of the tissue cells. Some of these messenger molecules are synthesized in adjacent tissues while others are synthesized within the responding tissues themselves.

DKK 434.00
1

The Morphology and Pathogenicity of the Bladder Worms - J. Slais - Bog - Springer - Plusbog.dk

The Morphology and Pathogenicity of the Bladder Worms - J. Slais - Bog - Springer - Plusbog.dk

The larval stage of taeniid cestodes, called the cysticercus, develops in the intermediate host from the oncosphere. The infection caused by cysticerci is called cysticercosis. Man is the only definitive host of two adult cestode species. One of them is the cestode Taenia solium Linne, 1758. Its larva is called Cysticercus cellulosae developing mostly in the muscles of swine. The other is Taeniarhynchus saginatus Goeze, 1782 and its larva Cysticercus bovis (C. inermis) develops in the muscles of cattle. Man can carry a cysticercus being its intermediate host, and suffer from cysticercosis. Because cysticerci are localized in the muscles of livestock, various measures have to be taken to prevent an infection of man with the adult cestode. These include a very strict inspection of the carcasses at the abattoir, a special treatment of infected meat or a certificate declaring it unfit for human consumption. The incidence of hu- man tapeworms, being still relatively high in the population, can be controlled suc- cessfully only by a comprehensive programme of eradication of muscle cysticercosis. There is no exact information available on fundamental processes in the biology of the cysticercus such as its development, its initial growth in the muscles, its meta- bolism, the length of its life, the reaction of the host, the possibility of spontaneous healing. Such knowledge is not only of theoretical importance, but indispensable for successful control of the parasites and for the serological diagnosis of cysticercosis.

DKK 646.00
1

Advances in Clinical Nutrition - - Bog - Springer - Plusbog.dk

Advances in Clinical Nutrition - - Bog - Springer - Plusbog.dk

The advent of any new and effective therapy is soon followed by large numbers of publications in which the indications and benefits are explored critically. It is not unexpected, therefore, that within five years of the first Bermuda Symposium on advances in parenteral nutrition that a second Symposium was considered appropriate to review progress and explore new areas of investigation, as well as enlarging the scope of the meeting to include enteral nutrition. The rate of progress can be judged by the number of subjects which were not discussed at the first Symposium. For example, home parenteral nutrition, computer assisted assessment and prescribing, Studies of body protein synthesis and breakdown and the role of branched-chain amino acids are all new subjects for this Symposium which were not covered at all in the first meeting. Much progress has also been made to our understanding of the biochemi­ cal complications of parenteral nutrition and the problems related to long term access to the circulation. Nutritional care has become safer and more effective. There is an increasing awareness of the difficulties in making a true nutritional assessment in selecting patients for total parenteral nutrition and more attention has also been focussed on different approaches to enteral support in the management of undernourished patients. There is also continuing debate on the cost effectiveness of this expensive method of treatment and critics look in vain for evidence of efficacy based on controlled trials in specific groups of patients.

DKK 434.00
1

Metabolic Adaptation to Extrauterine Life - - Bog - Springer - Plusbog.dk

Metabolic Adaptation to Extrauterine Life - - Bog - Springer - Plusbog.dk

th th st . On December 19 ,20 and 21 1979, we had the opportunlty to organize a Workshop on "Antenatal factors affecting meta­ bolic adaptation to extrauterine life - Role of carbohydra­ tes and energy metabolism". This meeting was made possible thanks to grants from the Committee of Medical Research and Public Health (CRM) of the Commission of European Communi­ ties. We want to express our warmst gratitude for the effort that has been made and we hope that the exchange of information between the participants will allow better understanding of the mechanism of adaptation to extrauterine life and that the conclusions drawn will contribute to a better care of the newborn. Adaptation to extrauterine life is one of the most impor­ tant steps in life. At the moment of birth, numerous conditions are drastically changed and in order to survive the newborn has to rely upon new sources of energy and of substrates. This switch over has to occur smoothly and any adaptation failure will result in the disturbance of impor­ tant metabolic functions. Mortality and morbidity in neo­ natal period remain still very high in comparison with the figures observed later in life; the reduction of mortality has been much more important in child and adult than in neonates.

DKK 434.00
1

Fear and Anxiety in Virtual Reality - Investigations of cue and context conditioning in virtual environment - Bog af Hannah Genheimer - Paperback

Fear and Anxiety in Virtual Reality - Investigations of cue and context conditioning in virtual environment - Bog af Hannah Genheimer - Paperback

Virtual realities provide an outstanding tool in anxiety research. Hannah Genheimer describes the scientific background of fear and anxiety and presents an empirical study in a highly controlled virtual environment. Psychophysiological as well as subjective data on the participants' fear and anxiety clearly show contextual fear conditioning.

DKK 634.95
2