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T-Cell Lymphomas - - Bog - Humana Press Inc. - Plusbog.dk

T-Cell Lymphomas - - Bog - Humana Press Inc. - Plusbog.dk

The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells. This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.

DKK 877.00
1

Helper T Cells - - Bog - Nova Science Publishers Inc - Plusbog.dk

Helper T Cells - - Bog - Nova Science Publishers Inc - Plusbog.dk

Helper T Cells: Types, Functions and New Research presents current research in the Tfh cell research field with a special focus on the maintenance of TFH cells and their fate once the immune response has resolved. Whereas early steps of Tfh cell generation have been the subject of intense research in recent years, much less is known about signals controlling Tfh cells in late phases of the germinal center reaction and their differentiation into long-term memory cells. The authors also discuss emerging evidence that CD4+ T cells orchestrate antitumor immunity by providing critical immunological help to B cells, facilitating isotype switching and affinity maturation, and CD8+ T cells, promoting effector and memory differentiation, as well as shaping innate immunity and the tumor microenvironment. While preventing autoimmunity, selective CD4+ T-cell tolerance also compromises immunity to malignant cells that express primarily self-antigens by eliminating CD4+ T-cell help for B-cell, CD8+ T-cell, and innate immune responses. Therefore, the authors suggest that the goal of cancer immunotherapeutics should be increasingly focused on overcoming the CD4+ T-cell tolerance barrier to negate the effects of tolerance-driven immune suppression and maximize antitumor responses. Next, data is presented showing that AIT reduces the expression of CD40L glycoprotein on T CD4+ cells from patients with pollen or Hymenoptera venom allergy when were treated with specific immunotherapy compared to patients not subject to treatment. The function of CD4 T lymphocytes in the development of allergy is discussed, along with the recent results obtained about the impact of AIT on CD40L expression on T helper lymphocytes of patients.

DKK 820.00
1

T-SQL Querying - Kevin Farlee - Bog - Microsoft Press,U.S. - Plusbog.dk

T-SQL Querying - Kevin Farlee - Bog - Microsoft Press,U.S. - Plusbog.dk

T-SQL insiders help you tackle your toughest queries and query-tuning problems Squeeze maximum performance and efficiency from every T-SQL query you write or tune. Four leading experts take an in-depth look at T-SQL’s internal architecture and offer advanced practical techniques for optimizing response time and resource usage. Emphasizing a correct understanding of the language and its foundations, the authors present unique solutions they have spent years developing and refining. All code and techniques are fully updated to reflect new T-SQL enhancements in Microsoft SQL Server 2014 and SQL Server 2012. Write faster, more efficient T-SQL code: - - Move from procedural programming to the language of sets and logic - - Master an efficient top-down tuning methodology - - Assess algorithmic complexity to predict performance - - Compare data aggregation techniques, including new grouping sets - - Efficiently perform data-analysis calculations - - Make the most of T-SQL’s optimized bulk import tools - - Avoid date/time pitfalls that lead to buggy, poorly performing code - - Create optimized BI statistical queries without additional software - - Use programmable objects to accelerate queries - - Unlock major performance improvements with In-Memory OLTP - - Master useful and elegant approaches to manipulating graphs - About This Book - - For experienced T-SQL practitioners - - Includes coverage updated from Inside Microsoft SQL Server 2008 T-SQL Querying and Inside Microsoft SQL Server 2008 T-SQL Programming - - Valuable to developers, DBAs, BI professionals, and data scientists - - Covers many MCSE 70-464 and MCSA/MCSE 70-461 exam topics -

DKK 794.00
1

CAR-T Manufacturing - - Bog - Taylor & Francis Ltd - Plusbog.dk

CAR-T Manufacturing - - Bog - Taylor & Francis Ltd - Plusbog.dk

This edited volume describes innovations in all steps of the CAR-T manufacturing chain. These vital descriptions will help practitioners to overcome current challenges during the process and vastly reduce costs and enable timely and accessible administration of CAR-T therapy to patients. The book provides readers with information on key fundamental concepts of CAR-T manufacturing in areas such as cell selection, cell activation, cell transfection, cell expansion, genetic engineering, and quality control. In each chapter, a particular technological field in the CAR-T manufacturing chain is discussed. Each chapter will include an introduction to the importance of a particular technology for cell manufacturing, comparisons of state-of-the-art methods, and discussions on respective emerging innovations. This exposes readers to a high-level view of the entire process while diving into details for each specific process step. Readers will be able to apply their knowledge to make changes at each step of the CAR-T manufacturing process to reduce the existing high costs and long production times, so that cancer patients globally can benefit from CAR-T therapy. This book is an invaluable resource for practitioners in CAR-T manufacturing who aim to improve their quality and efficiency while reducing time and costs. It is also useful for advanced undergraduate and graduate students who wish to gain a strong foundation for continuing research in the field or interacting with practitioners.

DKK 825.00
1

Collected Essays of N. T. Wright Set - Wright N. T. Wright - Bog - Zondervan Academic - Plusbog.dk

Collected Essays of N. T. Wright Set - Wright N. T. Wright - Bog - Zondervan Academic - Plusbog.dk

Collected Essays of N. T. Wright brings together N. T. Wright''s most important articles on Scripture and hermeneutics, Jesus and the Gospels, and Paul and his Letters over the last three decades. Here is a rich feast for all serious students of the New Testament. Each essay in this three-volume collection will amply reward those looking for detailed, incisive, and exquisitely nuanced exegesis, resulting in a clearer, deeper and more informed appreciation of Scripture and its application to Christian life and thought today.

DKK 1026.00
1

CAR T-Cell, An Issue of Hematology/Oncology Clinics of North America - - Bog - Elsevier Health Sciences - Plusbog.dk

CAR T-Cell, An Issue of Hematology/Oncology Clinics of North America - - Bog - Elsevier Health Sciences - Plusbog.dk

In this issue of Hematology/Oncology Clinics, guest editors Drs. Caron A. Jacobson and Parth S. Shah bring their considerable expertise to the topic of CAR T-Cell Therapy. Top experts in the field discuss the multiple ways CAR T-cell therapy can be used to help fight a variety of cancers, such as diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, mantle cell lymphoma, multiple myeloma, and B-cell acute lymphoblastic leukemia (ALL). - - Contains 12 practice-oriented topics including CAR T-cells in aggressive B-cell lymphomas; CAR T-cells in multiple myeloma; CAR T-cells in AML; mechanisms of resistance of CAR T-cell therapy; the role of CAR T-cell therapy in the era of bispecific antibodies; and more. - - Provides in-depth clinical reviews on CAR T-cell therapy, offering actionable insights for clinical practice. - - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

DKK 983.00
1

T Level Engineering - Andrew Livesey - Bog - Taylor & Francis Ltd - Plusbog.dk

T Level Engineering - Andrew Livesey - Bog - Taylor & Francis Ltd - Plusbog.dk

T Level Engineering is the new technical qualification standing alongside the Academic A Levels, for 16+ students looking to go into engineering. T Level Engineering covers the core elements for all the pathways of this qualification. Whether your sights are set on an engineering university degree, or an advanced apprenticeship, this book covers the essentials needed to get through the 2-year T Level Engineering program. Teachers and work placement managers will like it too as all the sections are broken down into bite-sized pieces – enough for a lesson or two. You should find T Level Engineering easy to understand and readily accessible, even if you have no previous engineering knowledge. The technical terms are explained as they are introduced, and a detailed glossary allows you to check out any specific terms, which is also very useful when writing assignments. You will keep this book handy even after your course has finished and it will provide a reference for a lifetime.

DKK 854.00
1

The New Way - Tam T. T. Ngo - Bog - University of Washington Press - Plusbog.dk

The New Way - Tam T. T. Ngo - Bog - University of Washington Press - Plusbog.dk

In the mid-1980s, a radio program with a compelling spiritual message was accidentally received by listeners in Vietnam's remote northern highlands. The Protestant evangelical communication had been created in the Hmong language by the Far East Broadcasting Company specifically for war refugees in Laos. The Vietnamese Hmong related the content to their traditional expectation of salvation by a Hmong messiah-king who would lead them out of subjugation, and they appropriated the evangelical message for themselves. Today, the New Way (Kev Cai Tshiab) has some three hundred thousand followers in Vietnam. Tam T. T. Ngo reveals the complex politics of religion and ethnic relations in contemporary Vietnam and illuminates the dynamic interplay between local and global forces, socialist and postsocialist state building, cold war and post–cold war antagonisms, Hmong transnationalism, and U.S.-led evangelical expansionism.

DKK 970.00
1

Shirts, Shifts and Sheets of Fine Linen - Dr Pam Inder - Bog - Bloomsbury Publishing PLC - Plusbog.dk

Shirts, Shifts and Sheets of Fine Linen - Dr Pam Inder - Bog - Bloomsbury Publishing PLC - Plusbog.dk

Shirts, Shifts and Sheets of Fine Linen explores how the jobs of the ‘seamstress’ evolved in scope, and status, between 1600-1900. In the 17th and early 18th centuries, seamstressing was a trade for women who worked in linen and cotton, making men’s shirts, women’s chemises, underwear and baby linen; some of these seamstresses were consummate craftswomen, able to sew with stitches almost invisible to the naked eye. Few examples of their work survive, but those that do attest to their skill. However, as the ready-to-wear trade expanded in the 18th century, women who assembled these garments were also known as seamstresses, and by the 1840s, most seamstresses were outworkers for companies or entrepreneurs, paid unbelievably low rates per dozen for the garments they produced, notorious examples of downtrodden, exploited womenfolk. Drawing on a range of original and hitherto unpublished sources, including business diaries, letters and bills, Shirts, Shifts and Sheets of Fine Linen explores the seamstress’s change of status in the 19th century and the reasons for it, hinting at the resurgence of the trade today given so few women today are skilled at repairing and altering clothes. Illustrated with 60 images, the book brings seamstresses into focus as real people, granting new insights into working class life in 18th- and 19th-century Britain.

DKK 936.00
1