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Handbook of Single Molecule Fluorescence Spectroscopy - Alastair Smith - Bog - Oxford University Press - Plusbog.dk

Handbook of Single Molecule Fluorescence Spectroscopy - Alastair Smith - Bog - Oxford University Press - Plusbog.dk

Analytical measurements at the single molecule level under ambient conditions have become almost routine in the past few years. The application of this technology to fundamental studies of heterogeneity in biomolecular structure and dynamics, chemical and biological reaction kinetics, and photophysics provides a rich playground for molecular scientists. The potential use of single molecule detection for nanotechnology and quantum information processing is a new and almost unexplored area. This handbook is intended for those interested in a practical introduction to single molecule investigations using fluorescence techniques and places special emphasis on the practicalities of achieving single molecule resolution, analysing the resulting data and exploration of the applications in biophysics. It is ideal for graduate research students and others embarking on work in this exciting field.

DKK 530.00
1

Single Molecule Science - Dmitrii E. Makarov - Bog - Taylor & Francis Ltd - Plusbog.dk

Single Molecule Science - Dmitrii E. Makarov - Bog - Taylor & Francis Ltd - Plusbog.dk

The observation and manipulation of individual molecules is one of the most exciting developments in modern molecular science. Single Molecule Science: Physical Principles and Models provides an introduction to the mathematical tools and physical theories needed to understand, explain, and model single-molecule observations. This book explains the physical principles underlying the major classes of single-molecule experiments such as fluorescence measurements, force-probe spectroscopy, and nanopore experiments. It provides the framework needed to understand single-molecule phenomena by introducing all the relevant mathematical and physical concepts, and then discussing various approaches to the problem of interpreting single-molecule data. The essential concepts used throughout this book are explained in the appendices and the text does not assume any background beyond undergraduate chemistry, physics, and calculus. Every effort has been made to keep the presentation self-contained and derive results starting from a limited set of fundamentals, such as several simple models of molecular dynamics and the laws of probability. The result is a book that develops essential concepts in a simple yet rigorous way and in a manner that is accessible to a broad audience.

DKK 496.00
1

Single-Molecule Science - - Bog - Cambridge University Press - Plusbog.dk

Single-Molecule Science - - Bog - Cambridge University Press - Plusbog.dk

Single Molecule Science (SMS) has emerged from developing, using and combining technologies such as super-resolution microscopy, atomic force microscopy, and optical and magnetic tweezers, alongside sophisticated computational and modelling techniques. This comprehensive, edited volume brings together authoritative overviews of these methods from a biological perspective, and highlights how they can be used to observe and track individual molecules and monitor molecular interactions in living cells. Pioneers in this fast-moving field cover topics such as single molecule optical maps, nanomachines, and protein folding and dynamics. A particular emphasis is also given to mapping DNA molecules for diagnostic purposes, and the study of gene expression. With numerous illustrations, this book reveals how SMS has presented us with a new way of understanding life processes. A must-have for researchers and graduate students, as well as those working in industry, primarily in the areas of biophysics, biological imaging, genomics and structural biology.

DKK 967.00
1

The Moral Molecule - Paul J. Zak - Bog - Transworld Publishers Ltd - Plusbog.dk

The Moral Molecule - Paul J. Zak - Bog - Transworld Publishers Ltd - Plusbog.dk

Human beings can be so compassionate. They can also be shockingly cruel. What if there was a master control for human behaviour? Switch it on and people are loving and generous. Switch it off and they revert to violence and greed. Pioneering neuroeconomist Paul J. Zak has discovered just such a master switch: a molecule in the human brain.Zak’s colleagues call him Dr Love. They also call him the vampire economist. He and his research team have travelled from his laboratory in California to the jungles of Papua new Guinea via a summer garden in Devon, taking blood from people as they attend a wedding, make decisions with money, play football on the field, even jump from an aeroplane. Their experiments to measure a chemical in the bloodstream called oxytocin reveal the answers to those mysteries about why we make the decisions we do: why we are sometimes rational, at other times irrational; why men cheat more than women; how the moral molecule operates in the market place, and most importantly, once we understand the moral molecule, how we can consciously use it to make our lives better.

DKK 159.00
1

Ion and Molecule Transport in Lysosomes - - Bog - Taylor & Francis Ltd - Plusbog.dk

Ion and Molecule Transport in Lysosomes - - Bog - Taylor & Francis Ltd - Plusbog.dk

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research

DKK 496.00
1

The Most Beautiful Molecule - Hugh Aldersey Williams - Bog - John Wiley & Sons Inc - Plusbog.dk

The Most Beautiful Molecule - Hugh Aldersey Williams - Bog - John Wiley & Sons Inc - Plusbog.dk

The Most Beautiful Molecule "The molecule, buckminsterfullerene, is beautiful physically and intellectually. Its qualities, and even some of its properties, can be appreciated instantly and intuitively by nonscientists. Its uniqueness is bound to lead to novel applications-superconductivity is the leading contender at the moment." "The commercial potential of buckminsterfullerene has heightened the excitement and controversy in recent years, while the exact nature of the discovery process in 1985 has been the subject of a heated feud between the British and American scientists involved."-Hugh Aldersey-Williams Ten years ago, the discovery of buckminsterfullerene, a previously unknown form of carbon, stunned the scientific community, as much for the discovery itself as for the manner in which it came about. In the words of author Hugh Aldersey-Williams, it was an example of "classic bootleg science". The work was done on the back of other, funded projects, and when time would allow. Yet its commercial implications are probably immense. Now, with objectivity and insight, The Most Beautiful Molecule recounts the events leading up to this momentous discovery and chronicles the ongoing, often frenzied aftermath. Hugh Aldersey-Williams leads us on a thrilling expedition to the very forefront of modern chemistry research. Houston, Texas, 1985. Two industrious chemists discover a previously unknown form of carbon and christen it buckminsterfullerene, for its striking resemblance to American architect Richard Buckminster Fuller''s geodesic domes. This unusual molecule-also known as the buckyball-is composed of 60 carbon atoms arranged in a hollow sphere, with hexagonal and pentagonal configurations similar to those found on a soccer ball. Its near-perfect symmetry is just one reason why scientists have since dubbed it "the most beautiful molecule." The discovery of buckminsterfullerene-by American physicist and chemist Richard Smalley and British physical chemist Harry Kroto-rocked the scientific community. After all, generations believed graphite and diamond to be the only pure forms of carbon. How had this third form gone undetected? In fact, the actual discovery was merely the beginning of an intense-and ongoing-quest to master this newest form of the most basic of elements. Confirmation would take five years and launch an unprecedented flood of investigation and investment. The unique physical structure of buckminsterfullerene-a "cage" into which atoms of other materials may be inserted-had huge commercial potential and inspired scientists, industrial laboratories, and corporations alike. Backed by such giants as AT&T, DuPont, Exxon, and IBM, a highly competitive search for practical applications began-and continues. Possibilities range from the creation of a revolutionary rocket fuel to nanotechnology-the construction of microscopic "molecular machines"-to developments in the fight against AIDS. Here, then, is a fascinating, multilayered look at one of the most important scientific findings of our time. The Most Beautiful Molecule is a brain-teasing detective story, a marvelously detailed, inside look at the workings of the scientific community, and an exciting contemplation of what lies ahead. From the forefront of research in modern chemistry, author Hugh Aldersey-Williams offers, in his own words, "a celebration of the intimate world of physical science and its practitioners."

DKK 199.00
1

Every Molecule Tells a Story - Simon Cotton - Bog - Taylor & Francis Inc - Plusbog.dk

Every Molecule Tells a Story - Simon Cotton - Bog - Taylor & Francis Inc - Plusbog.dk

From cooking to medicine, from engineering to art, chemistry—the science of molecules—is everywhere. A celebration of the molecules of chemistry, Every Molecule Tells a Story celebrates the molecules responsible for the experiences of everyday life: the air we breathe; the water we drink; the chemicals that fuel our living; the steroids that give us sex; the colours of the seasons; the drugs that heal us; and the scented molecules that enrich our diet and our encounters with each other. You can’t see them, but you know that they are there. Unveiling the structures of poisonous "natural" substances and beneficial man-made molecules, this book brushes away any preconceived notions about chemistry to demonstrate why and how molecules matter.

DKK 993.00
1

Every Molecule Tells a Story - Simon Cotton - Bog - Taylor & Francis Ltd - Plusbog.dk

Every Molecule Tells a Story - Simon Cotton - Bog - Taylor & Francis Ltd - Plusbog.dk

From cooking to medicine, from engineering to art, chemistry—the science of molecules—is everywhere. A celebration of the molecules of chemistry, Every Molecule Tells a Story celebrates the molecules responsible for the experiences of everyday life: the air we breathe; the water we drink; the chemicals that fuel our living; the steroids that give us sex; the colours of the seasons; the drugs that heal us; and the scented molecules that enrich our diet and our encounters with each other. You can’t see them, but you know that they are there. Unveiling the structures of poisonous "natural" substances and beneficial man-made molecules, this book brushes away any preconceived notions about chemistry to demonstrate why and how molecules matter.

DKK 477.00
1

Single-Molecule Studies of Nucleic Acids and Their Proteins - David (research Director And Professor Bensimon - Bog - Oxford University Press -

Single-Molecule Studies of Nucleic Acids and Their Proteins - David (research Director And Professor Bensimon - Bog - Oxford University Press -

This book provides the basis for understanding the elastic properties of nucleic acids (DNA, RNA), the methods used to manipulate them (e.g. optical, magnetic and acoustic tweezers and traps), and how to observe their interactions with proteins (e.g. fluorescence microscopy, FCS, FRET, etc.). It then exemplifies the use of these various methods in the study of three families of DNA enzymes: polymerases, helicases and topoisomerases. The book aims not to be exhaustive, but rather to stimulate the imagination of readers in the application of these single molecule approaches to the study of DNA/RNA and their interactions.

DKK 688.00
1

The Antibody Molecule - Anthony R. Biotage Ab Rees - Bog - Oxford University Press - Plusbog.dk

The Antibody Molecule - Anthony R. Biotage Ab Rees - Bog - Oxford University Press - Plusbog.dk

The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical sciences, immunology has a history that has seen chemists, physicists and biologists alike seeking to unravel the most complex system in the human body outside the brain. This book charts its intriguing history, from the genetic basis of antibody diversity, through the understanding of the mechanism by which the immune system''s first line of defence works, to breakthroughs in crystallography and the exploitation of immunoglobulins as therapeutic platforms to treat cancer, inflammation and allergy.Tracing the developments in immunology in chronological order, Professor Anthony R. Rees presents the historical contexts of the periods in rich detail, bringing them to life with quotes and illustrations. This fascinating book examines the literature of the time, turning points, and controversies. A must read for immunologists and life scientists, as well as historians of science and medicine.

DKK 903.00
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The Molecule of More - Daniel Z. Lieberman - Bog - - Plusbog.dk

The Molecule of More - Daniel Z. Lieberman - Bog - - Plusbog.dk

2020 Next Generation Indie Book Awards Winner - Science Category2018 Forward Indies Finalist - Psychology CategoryWhy are we obsessed with the things we want only to be bored when we get them? Why is addiction perfectly logical to an addict? Why does love change so quickly from passion to indifference? Why are some people die-hard liberals and others hardcore conservatives? Why are we always hopeful for solutions even in the darkest times—and so good at figuring them out? The answer is found in a single chemical in your brain: dopamine . Dopamine ensured the survival of early man. Thousands of years later, it is the source of our most basic behaviors and cultural ideas—and progress itself. Dopamine is the chemical of desire that always asks for more—more stuff, more stimulation, and more surprises. In pursuit of these things, it is undeterred by emotion, fear, or morality. Dopamine is the source of our every urge, that little bit of biology that makes an ambitious business professional sacrifice everything in pursuit of success, or that drives a satisfied spouse to risk it all for the thrill of someone new. Simply put, it is why we seek and succeed; it is why we discover and prosper. Yet, at the same time, it''s why we gamble and squander. From dopamine''s point of view, it''s not the having that matters. It''s getting something—anything—that''s new. From this understanding—the difference between possessing something versus anticipating it—we can understand in a revolutionary new way why we behave as we do in love, business, addiction, politics, religion—and we can even predict those behaviors in ourselves and others. In The Molecule of More: How a Single Chemical in Your Brain Drives Love, Sex, and Creativity—and will Determine the Fate of the Human Race , George Washington University professor and psychiatrist Daniel Z. Lieberman, MD, and Georgetown University lecturer Michael E. Long present a potentially life-changing proposal: Much of human life has an unconsidered component that explains an array of behaviors previously thought to be unrelated, including why winners cheat, why geniuses often suffer with mental illness, why nearly all diets fail, and why the brains of liberals and conservatives really are different.

DKK 162.00
1

Life, Death and Nitric Oxide - Rosslyn Nicholson - Bog - Royal Society of Chemistry - Plusbog.dk

Life, Death and Nitric Oxide - Rosslyn Nicholson - Bog - Royal Society of Chemistry - Plusbog.dk

Designated ''Molecule of the Year'' in 1992 in recognition of its many biological roles, nitric oxide has wide significance in the world around us and the story of nitric oxide is still unfolding. This small and seemingly innocent molecule has for many years been known to play a significant role in both the creation of photochemical smogs and in the nitrogen cycle. It has an interesting chemistry as a metal ligand, and the bonding within the nitric oxide molecule has been extensively studied. More recently, the molecule has been in the spotlight for the role it plays in controlling blood flow, in the immune system and in brain activity. Life, Death and Nitric Oxide covers many of the topics relating to nitric oxide, from smog and catalytic converters to tumour growth, blood flow and Viagra, with the aim of finding out why such a simple molecule can do so much.

DKK 278.00
1