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Physiological Consequences of Brain Insulin Action

Physiological Consequences of Brain Insulin Action

The brain is crucial for the regulation of whole-body metabolism and behavior. The pancreas-derived hormone insulin modulates brain function and affects energy metabolism as well as cognition. This is partially achieved by modulating several types of brain cell populations including those relevant to satiety and reward. Importantly brains of Alzheimer´s disease patients exhibit a signature of brain insulin resistance with perturbed brain metabolism. This book will cover the basics of insulin signaling in the brain and will describe concepts of insulin resistance a feature of type 2 diabetes. Moreover insulin´s effect on cognitive function will be pointed out and the association between brain insulin resistance and neurodegenerative diseases discussed. Additionally potential behavioral and pharmacological concepts which can affect brain insulin signaling will be summarized. Key Features: Summarizes insulin and the closely related IGF-1 receptor signaling Depicts concepts of insulin resistance Highlights the importance of conserved brain insulin signaling for brain function metabolism and behavior Describes potential behavioral and pharmacological approaches to support brain insulin signaling | Physiological Consequences of Brain Insulin Action

GBP 130.00
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Brain–Computer Interfaces Handbook Technological and Theoretical Advances

Brain–Computer Interfaces Handbook Technological and Theoretical Advances

Brain–Computer Interfaces Handbook: Technological and Theoretical Advances provides a tutorial and an overview of the rich and multi-faceted world of Brain–Computer Interfaces (BCIs). The authors supply readers with a contemporary presentation of fundamentals theories and diverse applications of BCI creating a valuable resource for anyone involved with the improvement of people’s lives by replacing restoring improving supplementing or enhancing natural output from the central nervous system. It is a useful guide for readers interested in understanding how neural bases for cognitive and sensory functions such as seeing hearing and remembering relate to real-world technologies. More precisely this handbook details clinical therapeutic and human-computer interfaces applications of BCI and various aspects of human cognition and behavior such as perception affect and action. It overviews the different methods and techniques used in acquiring and pre-processing brain signals extracting features and classifying users’ mental states and intentions. Various theories models and empirical findings regarding the ways in which the human brain interfaces with external systems and environments using BCI are also explored. The handbook concludes by engaging ethical considerations open questions and challenges that continue to face brain–computer interface research. Features an in-depth look at the different methods and techniques used in acquiring and pre-processing brain signals extracting features and classifying the user's intention Covers various theories models and empirical findings regarding ways in which the human brain can interface with the systems or external environments Presents applications of BCI technology to understand various aspects of human cognition and behavior such as perception affect action and more Includes clinical trials and individual case studies of the experimental therapeutic applications of BCI Provides human factors and human-computer interface concerns in the design development and evaluation of BCIs Overall this handbook provides a synopsis of key technological and theoretical advances that are directly applicable to brain–computer interfacing technologies and can be readily understood and applied by individuals with no formal training in BCI research and development. | Brain–Computer Interfaces Handbook Technological and Theoretical Advances

GBP 99.99
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Brain Computer Interface EEG Signal Processing

Brain Computer Interface EEG Signal Processing

Brain Computer Interface: EEG Signal Processing discusses electroencephalogram (EEG) signal processing using effective methodology and algorithms. This book provides a basic introduction to EEG and a classification of different components present in EEG. It also helps the reader to understand the scope of processing EEG signals and their associated applications. Further it covers specific aspects such as epilepsy detection; exploitation of P300 for various applications; design of an EEG acquisition system; and detection of saccade fix and blink from EEG and EOG data. Key Features: Explains the basis of brain computer interface and how it can be established using different EEG signal characteristics Covers the detailed classification of different types of EEG signals with respect to their physical characteristics Explains detection and diagnosis of epileptic seizures from the EEG data of a subject Reviews the design and development of a low-cost and robust EEG acquisition system Provides mathematical analysis of EEGs including MATLAB® codes for students to experiment with EEG data This book is aimed at graduate students and researchers in biomedical electrical electronics communication engineering healthcare and cyber physical systems. | Brain Computer Interface EEG Signal Processing

GBP 105.00
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Nanobrain The Making of an Artificial Brain from a Time Crystal

Nanobrain The Making of an Artificial Brain from a Time Crystal

Making an artificial brain is not a part of artificial intelligence. It will be a revolutionary journey of mankind exploring a science where one cannot write an equation a material will vibrate like geometric shape and then those shapes will change to make decisions. Geometry of silence plays like a musical instrument to mimic a human brain; our thoughts imagination everything would be a 3D shape playing as music; composing music would be the brain’s singular job. For a century the Turing machine ruled human civilization; it was believed that irrespective of complexity all events add up linearly. This book is a thesis to explore the science of decision-making where events are 3D-geometric shapes events grow within and above never side by side. ​ The book documents inventions and discoveries in neuroscience computer science materials science mathematics and chemistry that explore the possibility of brain or universe as a time crystal. The philosophy of Turing the philosophy of membrane-based neuroscience and the philosophy of linear sequential thought process are challenged here by considering that a nested time crystal encompasses the entire conscious universe. Instead of an algorithm the pattern of maximum free will is generated mathematically and that very pattern is encoded in materials such that its natural vibration integrates random events exactly similar to the way nature does it in every remote corner of our universe. Find how an artificial brain avoids any necessity for algorithm or programming using the pattern of free will. | Nanobrain The Making of an Artificial Brain from a Time Crystal

GBP 105.00
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Wearable Brain-Computer Interfaces Prototyping EEG-Based Instruments for Monitoring and Control

Wearable Brain-Computer Interfaces Prototyping EEG-Based Instruments for Monitoring and Control

This book presents a complete overview of the main EEG-based Brain-Computer Interface (BCI) paradigms and the related practical solutions for their design prototyping and testing. Readers will explore active reactive and passive BCI paradigms with an emphasis on the operation for developing solutions addressing the need for customization. Readers will familiarize themselves with the main steps for the realization of low-cost wearable BCIs which include: identification of the most suitable neuro signals for a specific application; definition of the hardware firmware and software with a focus on wearable non-invasive and low-cost solutions; development of algorithms for data processing and classification; and lastly experimental campaigns for the validation of the prototyped solutions. BCI systems based on electroencephalography (EEG) are investigated and a complete overview of all BCI paradigms is offered. The aim of this book is to drive the reader from the beginning to the end along a research-and-development process of a working BCI prototype. This book is a guide for designers biomedical engineers students biotechnologists and those in the biomedical instrumentation field that would like to conceive design prototype and test an innovative low-cost wearable EEG-based BCI. | Wearable Brain-Computer Interfaces Prototyping EEG-Based Instruments for Monitoring and Control

GBP 120.00
1

Sensing Sound Evolutionary Neurobiology of a Novel Sense of Hearing

Sensing Sound Evolutionary Neurobiology of a Novel Sense of Hearing

Hearing is a prerequisite for the evolution of language and thus the development of human societies. It is the only major sense whose evolution can be traced back to vertebrates starting with sarcopterygians. The book explores the evolution of auditory development that has remained largely unexplored in contemporary theories of neurosensory brain evolution including the telencephalon. It describes how sensory epithelia from the basilar papilla evolved in the ear and connected dedicated cochlear neurons to neuronal centers in the brain and deals with how sound is converted through sound modulations into reliably decoded messages. The loss of hearing with age is expected to reach 2. 6 billion people by 2050. As such the book explains and reviews hearing loss at the molecular level to the behavioral level and provides suggestions to manage the loss. | Sensing Sound Evolutionary Neurobiology of a Novel Sense of Hearing

GBP 145.00
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Basic Transesophageal and Critical Care Ultrasound

Basic Transesophageal and Critical Care Ultrasound

Basic Transesophageal and Critical Care Ultrasound provides an overview of transesophageal ultrasound of the heart lung and upper abdomen as well as basic ultrasound of the brain lung heart abdomen and vascular system. Ultrasound-guided procedures commonly used in critically ill patients are also covered. With more than 400 clinical images this well-illustrated text and its accompanying videos demonstrate new developments and challenges for those interested in mastering basic transesophageal echocardiography (TEE) and bedside surface ultrasound. Each chapter is presented in an easy-to-read format that includes color diagrams and ultrasound images which optimize interactive learning for both novice and experienced clinicians. The book is divided into two parts. The first is dedicated to basic TEE while the second provides focused coverage of bedside ultrasound. The book also includes chapters on extra-cardiac TEE and ultrasound of the brain—unconventional areas that will become more important in the future as clinicians evaluate not only the etiology of hemodynamic instability but also the impact on multiple organs and systems such as the kidney liver splanchnic perfusion and brain. This text is an invaluable resource to those preparing for the National Board of Echocardiography’s Examination of Special Competence in Basic Perioperative Transesophageal Echocardiography (PTEeXAM) and its equivalents outside the USA and Canada. In addition it prepares physicians for the American College of Chest Physician’s critical care ultrasound certification. The contents follow the syllabus of the TEE basic echo exam to ensure complete coverage of a trainee's requirements. It also includes sample questions and two helpful mock exams. Written by a multidisciplinary team of experts in TEE the book is a must-have for those in training and in practice.

GBP 170.00
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Computational Techniques in Neuroscience

Computational Techniques in Neuroscience

The text discusses the techniques of deep learning and machine learning in the field of neuroscience engineering approaches to study the brain structure and dynamics convolutional networks for fast energy-efficient neuromorphic computing and reinforcement learning in feedback control. It showcases case studies in neural data analysis. Features: Focuses on neuron modeling development and direction of neural circuits to explain perception behavior and biologically inspired intelligent agents for decision making Showcases important aspects such as human behavior prediction using smart technologies and understanding the modeling of nervous systems Discusses nature-inspired algorithms such as swarm intelligence ant colony optimization and multi-agent systems Presents information-theoretic control-theoretic and decision-theoretic approaches in neuroscience. Includes case studies in functional magnetic resonance imaging (fMRI) and neural data analysis This reference text addresses different applications of computational neuro-sciences using artificial intelligence deep learning and other machine learning techniques to fine-tune the models thereby solving the real-life problems prominently. It will further discuss important topics such as neural rehabili-tation brain-computer interfacing neural control neural system analysis and neurobiologically inspired self-monitoring systems. It will serve as an ideal reference text for graduate students and academic researchers in the fields of electrical engineering electronics and communication engineering computer engineering information technology and biomedical engineering. | Computational Techniques in Neuroscience

GBP 120.00
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Biometry Technology Trends and Applications

Biometry Technology Trends and Applications

Biometrics provide quantitative representations of human features physiological and behavioral. This book is a compilation of biometric technologies developed by various research groups in Tecnologico de Monterrey Mexico. It provides a summary of biometric systems as a whole explaining the principles behind physiological and behavioral biometrics and exploring different types of commercial and experimental technologies and current and future applications in the fields of security military criminology healthcare education business and marketing. Examples of biometric systems using brain signals or electroencephalography (EEG) are given. Mobile and home EEG use in children’s natural environments is covered. At the same time some examples focus on the relevance of such technology in monitoring epileptic encephalopathies in children. Using reliable physiological signal acquisition techniques functional Human Machine Interfaces (HMI) and Brain-Computer Interfaces (BCI) become possible. This is the case of an HMI used for assistive navigation systems controlled via voice commands head and eye movements. A detailed description of the BCI framework is presented and applications of user-centered BCIs oriented towards rehabilitation human performance and treatment monitoring are explored. Massive data acquisition also plays an essential role in the evolution of biometric systems. Machine learning deep learning and Artificial Intelligence (AI) are crucial allies here. They allow the construction of models that can aid in early diagnosis seizure detection and data-centered medical decisions. Such techniques will eventually lead to a more concise understanding of humans. | Biometry Technology Trends and Applications

GBP 130.00
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Essentials of Functional MRI

Essentials of Functional MRI

During the last two decades new developments in functional MRI (magnetic resonance imaging) have made it possible to detect changes in the brain over time as opposed to the snapshot produced by conventional MRI. Essentials of Functional MRI breaks down the technical challenges for physicians researchers and technologists who use functional MRI but may not be experts in the necessary math and physics. The author describes the theory and practical details of functional MRI (fMRI) methodology including how to acquire and analyze images and a wide range of examples demonstrate how fMRI has been used thus far. The author provides the essential information to study understand use and teach the practical aspects of fMRI for those people who are most likely to extend its use into clinical practice.

GBP 175.00
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Medical Imaging Artificial Intelligence Image Recognition and Machine Learning Techniques

Medical Imaging Artificial Intelligence Image Recognition and Machine Learning Techniques

Winner of the Outstanding Academic Title recognition by Choice for the 2020 OAT Awards. The Choice OAT Award represents the highest caliber of scholarly titles that have been reviewed by Choice and conveys the extraordinary recognition of the academic community. The book discusses varied topics pertaining to advanced or up-to-date techniques in medical imaging using artificial intelligence (AI) image recognition (IR) and machine learning (ML) algorithms/techniques. Further coverage includes analysis of chest radiographs (chest x-rays) via stacked generalization models TB type detection using slice separation approach brain tumor image segmentation via deep learning mammogram mass separation epileptic seizures breast ultrasound images knee joint x-ray images bone fracture detection and labeling and diabetic retinopathy. It also reviews 3D imaging in biomedical applications and pathological medical imaging. | Medical Imaging Artificial Intelligence Image Recognition and Machine Learning Techniques

GBP 130.00
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Bio-Inspired Fault-Tolerant Algorithms for Network-on-Chip

Bio-Inspired Fault-Tolerant Algorithms for Network-on-Chip

Network on Chip (NoC) addresses the communication requirement of different nodes on System on Chip. The bio-inspired algorithms improve the bandwidth utilization maximize the throughput and reduce the end-to-end latency and inter-flit arrival time. This book exclusively presents in-depth information regarding bio-inspired algorithms solving real world problems focussing on fault-tolerant algorithms inspired by the biological brain and implemented on NoC. It further documents the bio-inspired algorithms in general and more specifically in the design of NoC. It gives an exhaustive review and analysis of the NoC architectures developed during the last decade according to various parameters. Key Features: Covers bio-inspired solutions pertaining to Network-on-Chip (NoC) design solving real world examples Includes bio-inspired NoC fault-tolerant algorithms with detail coding examples Lists fault-tolerant algorithms with detailed examples Reviews basic concepts of NoC Discusses NoC architectures developed-to-date | Bio-Inspired Fault-Tolerant Algorithms for Network-on-Chip

GBP 115.00
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Assistive Technology Assessment Handbook

Assistive Technology Assessment Handbook

Assistive Technology Assessment Handbook Second Edition proposes an international ideal model for the assistive technology assessment process outlining how this model can be applied in practice to re-conceptualize the phases of an assistive technology delivery system according to the biopsychosocial model of disability. The model provides reference guidelines for evidence-based practice guiding both public and private centers that wish to compare evaluate and improve their ability to match a person with the correct technology model. This second edition also offers a contribution to the Global Cooperation on Assistive Technology (GATE) initiative whose activities are strongly focused on the assistive products service delivery model. Organized into three parts the handbook: gives readers a toolkit for performing assessments; describes the roles of the assessment team members among them the new profession of psychotechnologist; and reviews technologies for rehabilitation and independent living including brain–computer interfaces exoskeletons and technologies for music therapy. Edited by Stefano Federici and Marcia J. Scherer this cross-cultural handbook includes contributions from leading experts across five continents offering a framework for future practice and research.

GBP 160.00
1

Alcoholism Causes Symptoms Effects and Treatment

Alcoholism Causes Symptoms Effects and Treatment

The book includes research on multi-dimensional aspects of problems related to alcohol. The chapters cover a wide range of topics on the theme of Alcoholism ranging from reasons and factors that induce alcoholism to health risks and finally possible medical psychological and alternative remedial measures. Various factors such as genetics childhood influences antisocial behaviour and personality traits contribute to this menace of alcoholism. Cultural values beliefs and childhood experiences to govern thought process are indirectly related to earlier stages of alcohol addiction. Family history and life stress have implications on an individual's susceptibility to alcohol addiction. Personality traits influence the addiction in individuals. The treatment of alcoholism involves different therapies besides medicines for comprehensive and smooth recovery of the person. The important inducing factors impact on society individual brain family nutritional deficiency and possible therapies such as body psychotherapies herbal and natural therapy have been covered in the book in hope of a comprehensive solution. Note: T& F does not sell or distribute the Hardback in India Pakistan Nepal Bhutan Bangladesh and Sri Lanka. | Alcoholism Causes Symptoms Effects and Treatment

GBP 99.99
1

Practical Biomedical Signal Analysis Using MATLAB

Practical Biomedical Signal Analysis Using MATLAB

Covering the latest cutting-edge techniques in biomedical signal processing while presenting a coherent treatment of various signal processing methods and applications this second edition of Practical Biomedical Signal Analysis Using MATLAB® also offers practical guidance on which procedures are appropriate for a given task and different types of data. It begins by describing signal analysis techniques—including the newest and most advanced methods in the field—in an easy and accessible way illustrating them with Live Script demos. MATLAB® routines are listed when available and freely available software is discussed where appropriate. The book concludes by exploring the applications of the methods to a broad range of biomedical signals while highlighting common problems encountered in practice. These chapters have been updated throughout and include new sections on multiple channel analysis and connectivity measures phase-amplitude analysis functional near-infrared spectroscopy fMRI (BOLD) signals wearable devices multimodal signal analysis and brain-computer interfaces. By providing a unified overview of the field this book explains how to integrate signal processing techniques in biomedical applications properly and explores how to avoid misinterpretations and pitfalls. It helps readers to choose the appropriate method as well as design their own methods. It will be an excellent guide for graduate students studying biomedical engineering and practicing researchers in the field of biomedical signal analysis. Features: Fully updated throughout with new achievements technologies and methods and is supported with over 40 original MATLAB Live Scripts illustrating the discussed techniques suitable for self-learning or as a supplement to college courses Provides a practical comparison of the advantages and disadvantages of different approaches in the context of various applications Applies the methods to a variety of signals including electric magnetic acoustic and optical Katarzyna J. Blinowska is a Professor emeritus at the University of Warsaw Poland where she was director of Graduate Studies in Biomedical Physics and head of the Department of Biomedical Physics. Currently she is employed at the Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences. She has been at the forefront in developing new advanced time-series methods for research and clinical applications. Jarosław Żygierewicz is a Professor at the University of Warsaw Poland. His research focuses on developing methods for analyzing EEG and MEG signals brain-computer interfaces and applications of machine learning in signal processing and classification.

GBP 105.00
1

Carpenter's Neurophysiology A Conceptual Approach

Carpenter's Neurophysiology A Conceptual Approach

Neurophysiology: A Conceptual Approach offers a refreshing alternative to ‘learning by rote’. Under new authorship the sixth edition preserves the legacy of the original author the late Roger Carpenter retaining the concise approach and readable style so central to its predecessors. Integrating the disciplines of neurology and neuroscience with an emphasis on principles and functional concepts this comprehensive textbook covers the entire subject of neurophysiology from the conduction of nerve impulses to the higher functions of the brain within a single accessible volume. Key Features: Everything the student of medicine or physiology needs to understand neurophysiology. Blends successfully the principles of neuroscience with clinical manifestations in line with modern undergraduate curriculums. Revised and updated with a particular focus on proprioception skin sense and hearing including developments in cochlear implants and functional MRI Over 500 illustrations accompanied by full figure legends also available as a download for use in presentations. Choice of PB with bundled ebook durable HB or ebook only for complete flexibility Full of explanatory colour diagrams the book remains an unrivalled ‘one-stop shop’ for students of medicine physiology and applied physiology neurophysiology neuroscience and other bioscience disciplines seeking an integrated introduction to the challenging disciplines of neuroscience and neurology. | Carpenter's Neurophysiology A Conceptual Approach

GBP 110.00
1

Anxiety Gut Microbiome and Nutraceuticals Recent Trends and Clinical Evidence

Anxiety Gut Microbiome and Nutraceuticals Recent Trends and Clinical Evidence

Healthy gut function is associated with normal central nervous system (CNS) function. Hormones neurotransmitters and immunological factors released from the gut are known to send signals to the brain either directly or via autonomic neurons. Recently studies have emerged focusing on variations in the microbiome and the effect on various CNS disorders including but not limited to anxiety depressive disorders schizophrenia and autism. Anxiety Gut Microbiome and Nutraceuticals: Recent Trends and Clinical Evidence is focused on understanding the role of gut microbiomes on anxiety and how it can be treated using various nutraceuticals. It covers recent trends and clinical evidence in application of nutraceuticals in treating anxiety and related disorders. Key Features Explains various factors related to anxiety and anxiety-related disorders including pathophysiological and pharmacological factors Discusses the pharmacology behind anxiety and related disorders Explores the role of gut microbiota and its relationship with anxiety and related disorders Describes different nutraceuticals and classes of nutraceuticals which can be useful to treat anxiety and related disorders In recent years there has been an increased interest in nutraceuticals and their applications in treating many diseases and disorders. The market has grown tremendously and this book focuses on the many clinical studies reporting on the usefulness of nutraceuticals in treating such health conditions. | Anxiety Gut Microbiome and Nutraceuticals Recent Trends and Clinical Evidence

GBP 170.00
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Bioengineered Nanomaterials

Bioengineered Nanomaterials

Many varieties of new complex diseases are constantly being discovered which leaves scientists with little choice but to embrace innovative methods for controlling the invasion of life-threatening problems. The use of nanotechnology has given scientists an opportunity to create nanomaterials that could help medical professionals in diagnosing and treating problems quickly and effectively. Bioengineered Nanomaterials presents in-depth information on bioengineered nanomaterials currently being developed in leading research laboratories around the world. In particular the book focuses on nanomaterials for biomedical applications. This collection brings together novel methodologies and strategies adopted in the research and development of bioengineered nanomaterials and technology. Renowned international researchers discuss topics including: Nanoemulsions as a vaccine adjuvant Bioceramic nanomaterials in medical applications Natural and synthetic nanoporous membranes for cell encapsulation therapy Inorganic nanoparticle materials for the controlled release of drugs Nanomedicine in brain tumor treatment Nanoparticles for the treatment of solid tumors and metastasis Near-infrared-resonant gold nanoshells and carbon nanotubes in tumor imaging Toxicity testing and bioapplications of silver nanoparticles Innovative approaches to improve bioactive properties and molecular signaling in cells to stimulate bone repair The book is written for readers from diverse backgrounds across chemistry physics materials science and engineering medical science pharmacy biotechnology and biomedical engineering. It offers a comprehensive view of cutting-edge research on nanomaterials of biotechnological importance.

GBP 89.99
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Prosthetic Biomechanics in Engineering

Prosthetic Biomechanics in Engineering

Prosthetic biomechanics is an interdisciplinary field of engineering medicine and biology focused on enhancing people’s lifestyles. In the past 20 years the field of prosthetic biomechanics and its potential have grown due to the support of advances in engineering technologies. Prosthetic Biomechanics in Engineering is about the recent advances in prosthetic engineering research. The scope of the book is focused on the design development and evaluation of a prosthetic systems that are being used in biomechanical applications. The book covers advanced materials conceptual design classification ergonomics design applications brain computer interface (BCI) system motion analysis postural stand stability upper and lower limb prosthetics types of suspension systems for prosthetics Fiber Bragg Grating-based techniques and pressure on the residual limb and the socket. The early chapters effectively describe new sensors for in-socket systems new pylon material and advanced gait analysis. Further chapters discuss advanced techniques for the design and development of prosthetics based on clinical and emergency uses. The information provided in this book is intended for researchers and investigators to encourage further advances in the field of prosthetics research and for the development of rehabilitation equipment for the improvement of human health and it: Presents recent advances in prosthetic biomechanics engineering research Discusses the design and development of limb prosthetic systems Explores advanced concepts of the prosthetic sockets Describes gait analysis of prosthetics and orthotics Dr Noor Azuan Abu Osman is a practicing engineer and Professor of Biomechanics with Department of Biomedical Engineering Faculty of Engineering University of Malaya Malaysia.

GBP 130.00
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Conditionally Toxic Proteins

Conditionally Toxic Proteins

Human health depends upon access to high-quality proteins for our diet and pharmaceutical use. This book deals with the nature of toxicity as it applies to proteins in food and drugs. Many proteins such as glutens and allergens are valuable food sources but toxic for sensitized individuals. Even proteins produced in the human body can become toxic through mutation or aggregation. For example Alzheimer's and Huntington's disease are characterized by plaques in the brain of insoluble protein aggregations. Paradoxically even toxins produced by the most pathogenic microorganisms such as Botox have found use in the clinic and industry. This book discusses how many proteins including interferons and cytokines can be valuable therapeutics while still associated with autoimmune diseases such as psoriasis or lupus erythematosus. Key Features: Shows why gluten proteins are different from all others and how this can account for symptoms throughout the body in those with celiac disease Illustrates that multiple allergy syndrome is not only real and related to similar allergens in extremely different plants Discusses the difficulties in using human proteins and cytokines as therapeutics Presents examples of how protein aggregates are vital to many physiological processes but also characterize renal and neurological syndromes Shows examples of protein toxins that have medical and industrial uses Related Titles Almeida P. Proteins: Concepts in Biochemistry (ISBN 978-0-8153-4502-2) Williamson M. How Proteins Work (ISBN 978-0-8153-4446-9) Lopata A. L. ed. Food Allergy: Molecular and Clinical Practice (ISBN 978-0-3677-8199-6) Wegrzyn R. D. & A. S. Rudolph eds. Alzheimer’s Disease: Targets of New Clinical Diagnostic and Therapeutic Strategies (ISBN 978-1-4398-2708-6) | Conditionally Toxic Proteins

GBP 89.99
1

Manual of Stroke Models in Rats

Manual of Stroke Models in Rats

During the last few years exciting new insights into mechanisms and treatment of stroke have been obtained from animal experiments. Hence the use of animal models to induce stroke are of paramount importance as research tools. While a few articles on this topic have been published in select journals until now there has not been a systematic technical book available which assists researchers in building upon commonly known knowledge. The Manual of Stroke Models in Rats explains in great detail the methods and techniques for accomplishing different stroke models in rats as well as some techniques using mice. Expert contributors to this text include the most recent research information available as well as generally recognized facts making this volume an imperative tool for those researchers seeking to identify new areas of exploration. The first text in 20 years to detail new techniques in rat stroke models The book begins with a statistical update of stroke in America and proceeds to discuss the rationale for using ischemic stroke models. Major sections include different surgical models of stroke induced by the occlusion of the distal middle cerebral artery by intraluminal filament or embolic implantation by photochemically induced thrombosis global cerebral ischemia induced by asphyxia cardiac arrest or by four-vessel occlusion and brain hemorrhage. The book also includes anesthesia procedures general principles of microsurgery and a study of microsurgical instruments. Numerous tables figures and color images are used to supplement the material. The editor Dr. Yanlin Wang-Fischer has published more than 40 scientific articles in various medical journals and contributed to several projects related to animal models and surgeries. In this volume she brings together contributors who represent the cutting edge of research in the field. By reviewing the methods in this detailed technical treatise research

GBP 175.00
1

Deep Learning Machine Learning and IoT in Biomedical and Health Informatics Techniques and Applications

Deep Learning Machine Learning and IoT in Biomedical and Health Informatics Techniques and Applications

Biomedical and Health Informatics is an important field that brings tremendous opportunities and helps address challenges due to an abundance of available biomedical data. This book examines and demonstrates state-of-the-art approaches for IoT and Machine Learning based biomedical and health related applications. This book aims to provide computational methods for accumulating updating and changing knowledge in intelligent systems and particularly learning mechanisms that help us to induce knowledge from the data. It is helpful in cases where direct algorithmic solutions are unavailable there is lack of formal models or the knowledge about the application domain is inadequately defined. In the future IoT has the impending capability to change the way we work and live. These computing methods also play a significant role in design and optimization in diverse engineering disciplines. With the influence and the development of the IoT concept the need for AI (artificial intelligence) techniques has become more significant than ever. The aim of these techniques is to accept imprecision uncertainties and approximations to get a rapid solution. However recent advancements in representation of intelligent IoTsystems generate a more intelligent and robust system providing a human interpretable low-cost and approximate solution. Intelligent IoT systems have demonstrated great performance to a variety of areas including big data analytics time series biomedical and health informatics. This book will be very beneficial for the new researchers and practitioners working in the biomedical and healthcare fields to quickly know the best performing methods. It will also be suitable for a wide range of readers who may not be scientists but who are also interested in the practice of such areas as medical image retrieval brain image segmentation among others. • Discusses deep learning IoT machine learning and biomedical data analysis with broad coverage of basic scientific applications • Presents deep learning and the tremendous improvement in accuracy robustness and cross- language generalizability it has over conventional approaches • Discusses various techniques of IoT systems for healthcare data analytics • Provides state-of-the-art methods of deep learning machine learning and IoT in biomedical and health informatics • Focuses more on the application of algorithms in various real life biomedical and engineering problems | Deep Learning Machine Learning and IoT in Biomedical and Health Informatics Techniques and Applications

GBP 140.00
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Secrets of the Moon Understanding and Analysing the Lunar Surface

Secrets of the Moon Understanding and Analysing the Lunar Surface

Secrets of the Moon: Understanding and Analysing the Lunar Surface provides a unique account of the origin of key features on the lunar surface. Containing historical accounts and the latest observations from the field in addition to exciting data from the Apollo manned missions it describes the development of our current understanding of our Moon. It also explores the fracturing of the Moon a topic not explored in other literature in the area and contains a statistical treatment of the smaller craters of the Moon as well as a geological treatment of the larger craters. This moderately technical account is designed to clarify and update the general thinking on the nature and origin of the most important lunar surface features for both undergraduate and research students. It may also be read by the professional scientist especially the astronomer and the geologist who has found little time to study the Moon’s topography in addition to the lunar amateur astronomer and even the dedicated layman with a keen interest in lunar science. The book excludes nearly all mathematical symbols in order to remain accessible to those without a formal education in the area. Key Features: Authored by an expert in the area Presents a comprehensive account of the lunar surface from historical observations to the NASA Apollo manned missions and the latest observations and data in the field Includes a statistical and geological treatment of the craters Dr. Gilbert Fielder is Reader Emeritus at Lancaster University United Kingdom. He performed extended teaching at Lancaster University on Planetary Science and introduced a new degree course on Remote Sensing. Prior to this he was Principal Investigator in NASA’s Heat Capacity Mapping Programme while continuing to head the Lunar and Planetary Unit at Lancaster until retirement. Dr. Fielder has authored several books and presented many BBC and ITA television news programmes as well as popular programmes with Sir Patrick Moore (on the BBC’s The Sky at Night) and on the occasion of the first landing of astronauts on the Moon with David Frost as Chairman in a special programme. | Secrets of the Moon Understanding and Analysing the Lunar Surface

GBP 150.00
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Manganese Removal from Groundwater Role of Biological and Physico-Chemical Autocatalytic Processes

Manganese Removal from Groundwater Role of Biological and Physico-Chemical Autocatalytic Processes

In The Netherlands Belgium and other European countries manganese is removed by conventional groundwater treatment with aeration and rapid (sand) filtration. Such a treatment process is easy to operate cost effective and sustainable because it does not make use of strong oxidants such as O3 Cl2 ClO2 and KMnO4 with the associated risk of by-product formation and over or under dosing. However application of aeration-filtration is also facing drawbacks especially the long ripening time of filter media. Due to the long ripening time water companies have to waste large volumes of treated water making this process less sustainable. Also costs associated with filter media ripening (man power electricity operational and analysis costs) are high. Therefore decreasing the filter ripening time regarding manganese removal is a big issue. Although already extended research has been carried out into manganese removal the controlling mechanisms especially of the start up face of filter media ripening are not fully understood yet. The emphasis of this thesis is to provide a better understanding of the mechanisms involved in the ripening of virgin filter media regarding manganese removal and how to shorten or completely eliminate the long ripening period of filters with virgin material. This thesis therefore highlights the role of the formation of a manganese oxide coating on virgin filter media. Characterization and identification revealed that the responsible manganese oxide for an effective manganese removal was Birnessite. It was found that Birnessite formed at the beginning of the ripening process was of a biological origin. Based on the knowledge that manganese removal in conventional groundwater treatment is initiated biologically long ripening times may be reduced by creating conditions favouring the growth of manganese oxidizing bacteria e. g. by limiting the back wash frequency and / or intensity. Additionally this thesis also shows that the use of freshly prepared manganese oxide containing Birnessite can completely eliminate filter media ripening time. | Manganese Removal from Groundwater Role of Biological and Physico-Chemical Autocatalytic Processes

GBP 99.99
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