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The Female Brain

The Female Brain

The first edition of The Female Brain laid the groundwork for gaining a better understanding of the female brain examining the evidence for structural and functional differences between the brains of males and females. Addressing a wealth of new research the second edition continues in this vein leading readers through the basic principles of anatomy and physiology and on to the complex behavioral functions which constitute the workings of the normal and abnormal female brain. Examines Questions about Structural and Functional Differences The book addresses the question of structural and functional differences between the female brain and the male brain. Are there differences? How good is the evidence? Where do the differences lie? Are there differences in the neuroanatomy of females and if so where? Do females and males process information differently and if so how? The author puts the relative lack of information on the female brain into historical perspective and reviews empirical evidence relevant to the different aspects of brain structure and function. She elucidates laterality the functional asymmetry of the brain the left brain-right brain distinctions and how they differ between females and males. A Clear Presentation and Evaluation of Medical and Scientific Evidence Filled with rigorous scientific analysis in an easily accessible format and detailed explanatory diagrams the book systematically develops the topic from anatomy to behavior. It draws on current research to explain why men and women behave differently and why these differences should be exploited when designing research and clinical studies.

GBP 69.99
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Neurophotonics and Brain Mapping

Transcranial Brain Stimulation

Nutrition and the Developing Brain

Traumatic Brain Injury: A Neurosurgeon's Perspective

Dietary Lipids for Healthy Brain Function

Dietary Lipids for Healthy Brain Function

Our brain is recognized by all specialists as the most complex entity created in nature. Regarding the extraordinary capacities of its functioning still incompletely known the control of the brain by our dietary lipids may seem very improbable to many people. Yet research has shown that an imbalance in the intake of essential fatty acids is related to conditions as prevalent as depression bipolar disorder and schizophrenia. Research on psychological disorders including attention deficit hyperactivity disorder autism aggressiveness and suicidal behavior are discussed in this text. Several neurodegenerative diseases such as Alzheimer's Parkinson's and multiple sclerosis are also explored. Several observations prove that not only are omega-3 fatty acids actively involved in maintaining the noble functions of our brain but other lipids including cholesterol liposoluble vitamins (A D and E) and some carotenoids play roles as well and are presented in this book. Dietary Lipids for Healthy Brain Function focuses on this important research for human health. This book brings readers doctors dietitians and nutritionists arguments that could improve brain development in young people prevent many nervous diseases and slow down the age-related decline of higher brain functions. This book provides helpful information to improve health in the young as well in the old using practical and personalized recommendations for preventing and treating nervous pathologies. Features:• Focuses on the importance of dietary lipids on the proper brain functioning. • Provides relevant references demonstrating the efficiency of dietary lipids to maintain a healthy brain. • Introduces lipid sources and describes their roles by lipid groups in behavior issues and various chronic nervous diseases.

GBP 44.99
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Astrocytes Wiring the Brain

Astrocytes Wiring the Brain

Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field Astrocytes: Wiring the Brain emphasizes cellular connections and surveys the most current findings on astrocyte activity. The first section of the book identifies major astrocyte biomarkers and describes how they define the different connectivity domains. Next the book examines the role of these connections. It explains how their function can be manipulated under physiological conditions and how dysfunction of the connectivity leads to aberrant brain performance. The final section explores the alterations of glia that have been observed in specific diseases of the brain. These include epilepsy autoimmune encephalitis Alzheimer’s disease autism and major depression. The book identifies key mechanisms responsible for these alterations. An important and emerging field astrocytes and their functions are critical to neuroscientists and neurologists both in academia and in industry particularly in the search for and development of new drugs to combat a variety of diseases affecting the CNS. As research continues to grow in this area this volume will spur heightened advances and understanding into the effects of these neural cells on a range of pathologies. | Astrocytes Wiring the Brain

GBP 59.99
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Brain Aging Models Methods and Mechanisms

Brain Aging Models Methods and Mechanisms

Recognition that aging is not the accumulation of disease but rather comprises fundamental biological processes that are amenable to experimental study is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur new possibilities emerge for limiting the effects of aging on neural function. A single source reference is necessary to keep abreast of the recent advances and future directions of gerontology research. Brain Aging: Models Methods and Mechanisms offers a selective overview of the research in this rapidly expanding field. A valuable resource for new and established investigators of the aging brain this volume reviews critical studies of brain aging in new animal models as well as advances in brain imaging techniques that permit investigations in aging humans with increasingly higher resolution. Detailed discussions link the information from human and animal studies to illustrate a comprehensive picture of the mechanism of aging. Emphasizing normal brain aging rather than pathological degeneration the text provides an understanding of fundamental age-related changes in the nervous system and hypothesis-driven research into their basis. The book includes critical analyses of the distinct methodological challenges inherent in investigating the aging nervous system. Contributions from distinguished leaders and pioneers in their respective fields address data and mechanisms as well as models and methods that are key to the study of aging. Each chapter is extensively referenced and highlights experimental concerns that are magnified or unique to the aging brain. Outlining relevant methods and techniques this book provides scientists researchers and clinicians with a broad understanding of the important progress and implications for the future of this significant field. | Brain Aging Models Methods and Mechanisms

GBP 56.99
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The Blood-Brain Barrier in Health and Disease Volume Two Pathophysiology and Pathology

The Microbiome and the Brain

The Microbiome and the Brain

Brain related disorders are among the most challenging health issues of our time. The development of effective therapeutic and preventive strategies for these disorders relies on a comprehensive understanding of the underlying causative mechanisms. And until recently these mechanisms have remained somewhat elusive. The newly discovered pivotal role of the intestinal microbiome in brain health functionality and resistance to disease is revolutionizing neuroscience. The Microbiome and the Brain through the contributions of some of the most forward thinking researchers and clinicians in the field comprehensively reveals the leading edge of our understanding of the fundamental role of gut microbes and their metabolites in a wide array of seemingly diverse brain issues including Alzheimer’s disease autism multiple sclerosis and mood disorders. In addition mechanisms defining these relationships are explored along with a presentation of the state-of-the-art as it relates to interpretation of relevant laboratory assessments. Finally novel therapeutic opportunities derived from this exciting science are presented. Readers will learn:The highly validated relationship between alterations of gut microbes and their metabolites and risk for Alzheimer’s disease. The important link between autism and intestinal dysbiosis. Appropriate interpretation of available laboratory assessments of the intestinal microbiome. The potential role of fecal microbial transplant in neurological diseases. The influence of diet and other lifestyle choices on the microbiome as it relates to brain health and functionality.

GBP 44.99
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Brain and Cognitive Intelligence Control in Robotics

Brain Tumors Practical Guide to Diagnosis and Treatment

Biomarkers of Brain Injury and Neurological Disorders

In Vivo Optical Imaging of Brain Function

In Vivo Optical Imaging of Brain Function

These are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques and their applications for the growing field of functional imaging in the live brain using optical imaging techniques. New in the Second Edition:Voltage-sensitive dyes imaging in awake behaving animalsImaging based on genetically encoded probesImaging of mitochondrial auto-fluorescence as a tool for cortical mappingUsing pH-sensitive dyes for functional mappingModulated imagingCalcium imaging of neuronal activity using 2-photon microscopyFourier approach to optical imagingFully updated chapters from the first editionLeading Authorities Explore the Latest Techniques Updated to reflect continuous development in this emerging research area this new edition as with the original reaches across disciplines to review a variety of non-invasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as biophysics neuroscience and cognitive science present a host of perspectives that range from a single neuron to large assemblies of millions of neurons captured at various temporal and spatial resolutions. Introducing techniques that were not available just a few years ago the authors describe the theory setup analytical methods and examples that highlight the advantages of each particular method.

GBP 59.99
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Mild Traumatic Brain Injury A Science and Engineering Perspective

Mild Traumatic Brain Injury A Science and Engineering Perspective

Mild traumatic brain injury (mTBI) directly related to chronic traumatic encephalopathy presents a crisis in contact sports the military and public health. Mild Traumatic Brain Injury: A Science and Engineering Perspective reviews current understanding of mTBI methods of diagnosis treatment policy concerns and emerging technologies. It details the neurophysiology and epidemiology of brain injuries by presenting disease models and descriptions of nucleating events characterizes sensors imagers and related diagnostic measures used for evaluating and identifying brain injuries and relates emerging bioinformatics analysis with mTBI markers. The book goes on to discuss issues with sports medicine and military issues; covers therapeutic strategies surgeries and future developments; and finally addresses drug trials and candidates for therapy. The broad coverage and accessible discussions will appeal to professionals in diverse fields related to mTBI students of neurology medicine and biology as well as policy makers and lay persons interested in this hot topic. Features Summarizes the entire scope of the field of mTBI Details the neurophysiology epidemiology and presents disease models and descriptions of nucleating events Characterizes sensors imagers and related diagnostic measures and relates emerging bioinformatics analysis with mTBI markers Discusses issues with sports medicine and military issues Covers therapeutic strategies surgeries and future developments and addresses drug trials and candidates Dr Mark Mentzer earned his PhD in Electrical Engineering from the University of Delaware. He is a former research scientist at the US Army Research Laboratory where he studied mild traumatic brain injury and developed early-detection brain injury helmet sensors. He is a certified test director and contracting officer representative. He possesses two Level-III Defense Acquisition University Certifications in Science and Technology Management and in Test and Evaluation. During his career he developed a wide range of sensors and instrumentation as well as biochemical processes to assess brain trauma. Mentzer currently teaches graduate systems engineering and computer science courses at the University of Maryland University College. | Mild Traumatic Brain Injury A Science and Engineering Perspective

GBP 44.99
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The Blood-Brain Barrier in Health and Disease Volume One Morphology Biology and Immune Function

The Blood-Brain Barrier in Health and Disease Volume One Morphology Biology and Immune Function

Located at the interface between blood and the brain the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability transport and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Over the last 25 years we have witnessed remarkable expansion of our knowledge of the structure biology and function of the cerebral endothelium. In The Blood-Brain Barrier in Health and Disease Volume 1 international experts discuss basic and new concepts and most recent advances pertaining to the development of the cerebral microvascular system. Subjects include the structure function permeability properties transport mechanisms and the inherent heterogeneity of the cerebral endothelium; the anatomy and physiological properties of the neurovascular unit; functional aspects of the choroid plexus; and important concepts and advances made over the last two decades that have shaped our understanding of the immunological function of the blood-brain barrier. This book is intended to serve as a valuable source of basic and advanced information for researchers students and clinicians interested in this fast-expanding field and stimulate further research well into the future. | The Blood-Brain Barrier in Health and Disease Volume One Morphology Biology and Immune Function

GBP 44.99
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Endocannabinoids The Brain and Body's Marijuana and Beyond

Endocannabinoids The Brain and Body's Marijuana and Beyond

Over the past decade there have been major advances in understanding the mechanisms whereby marijuana interacts with the brain in producing psychoactive and potentially therapeutic effects. The discovery of specific gene coding for cannabinoid receptors activated by smoking marijuana and the finding of endogenous cannabinoids which also activate the receptors have transformed cannabinoid research into mainstream science with significant implications in human health and disease Endocannabinoids: The Brain and Body’s Marijuana and Beyond documentsadvances in the discovery and functioning of naturally occurring marijuana-like substances in human biology. It explores recent findings that point to the existence of an endocannabinoid physiological control system (EPCS) that directly impacts human development health and disease. While cannabinoid effects on the brain have received the greatest attention throughout the literature this work looks at research on the endogenous cannabinoid system’s association across all of human physiology including the immune endocrine and reproductive systems. With thoroughly researched and exceptionally insightful contributions from more than three-dozen top-flight researchers representing a cross-section of disciplines from molecular biology genetics and neurology to gynecology physiology and pharmacology this work explores a range of topics as wide as the human body is complex. These topics include the EPCS’s relation to cell development and regulation CNS function immune function modulation reproduction and digestion as well as its function in mental illness neurodegenerative diseases and cancer. The final section in the book considers the significance of endogenous cannabinoids found in some of the simplest multicellular organisms in the animal kingdom as well as in mammalian cells at the earliest stages of development all of which suggests that they play a fundamental role in human biology. | Endocannabinoids The Brain and Body's Marijuana and Beyond

GBP 59.99
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Quantitative MRI of the Brain Principles of Physical Measurement Second edition

Quantitative MRI of the Brain Principles of Physical Measurement Second edition

Building on the success of the first edition of this book the winner of the 2004 British Medical Association Radiology Medical Book Competition Quantitative MRI of the Brain: Principles of Physical Measurement gives a unique view on how to use an MRI machine in a new way. Used as a scientific instrument it can make measurements of a myriad of physical and biological quantities in the human brain and body. For each small tissue voxel non-invasive information monitors how tissue changes with disease and responds to treatment. The book opens with a detailed exposition of the principles of good practice in quantification including fundamental concepts quality assurance MR data collection and analysis and improved study statistical power through minimised instrumental variation. There follow chapters on 14 specific groups of quantities: proton density T1 T2 T2* diffusion advanced diffusion magnetisation transfer CEST 1H and multi-nuclear spectroscopy DCE-MRI quantitative fMRI arterial spin-labelling and image analysis and finally a chapter on the future of quantification. The physical principles behind each quantity are stated followed by its biological significance. Practical techniques for measurement are given along with pitfalls and examples of clinical applications. This second edition of this indispensable 'how to' manual of quantitative MR shows the MRI physicist and research clinician how to implement these techniques on an MRI scanner to understand more about the biological processes in the patient and physiological changes in healthy controls. Although focussed on the brain most techniques are applicable to characterising tissue in the whole body. This book is essential reading for anyone who wants to use the gamut of modern quantitative MRI methods to measure the effects of disease its progression and its response to treatment. Features:The first edition was awarded the book prize for Radiology by the British Medical Association in 2004Written by an authority in the field: Professor Tofts has an international reputation for quantification in MRIGives specific ‘how to’ information for implementation of MRI measurement sequence techniques | Quantitative MRI of the Brain Principles of Physical Measurement Second edition

GBP 46.99
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The Human Brain during the Third Trimester 225– to 235–mm Crown-Rump Lengths Atlas of Central Nervous System Development Volume 11

The Gamer's Brain How Neuroscience and UX Can Impact Video Game Design

The Gamer's Brain How Neuroscience and UX Can Impact Video Game Design

Making a successful video game is hard. Even games that are well-received at launch may fail to engage players in the long term due to issues with the user experience (UX) that they are delivering. That’s why makers of successful video games like Fortnite and Assassin’s Creed invest both time and money perfecting their UX strategy. These top video game creators know that a bad user experience can ruin the prospects for any game regardless of its budget scope or ambition. The game UX accounts for the whole experience players have with a video game from first hearing about it to navigating menus and progressing in the game. UX as a discipline offers guidelines to assist developers in creating the optimal experience they want to deliver including shipping higher quality games (whether indie triple-A or serious games) and meeting business goals - all while staying true to design vision and artistic intent. At its core UX is about understanding the gamer’s brain: understanding human capabilities and limitations to anticipate how a game will be perceived the emotions it will elicit how players will interact with it and how engaging the experience will be. This book is designed to equip readers of all levels from student to professional with cognitive science knowledge and user experience guidelines and methodologies. These insights will help readers identify the ingredients for successful and engaging video games empowering them to develop their own unique game recipe more efficiently while providing a better experience for their audience. The Gamer's Brain: How Neuroscience and UX Can Impact Video Game Design Is written by Celia Hodent - a UX expert with a PhD in psychology who has been working in the entertainment industry for over 10 years including at prominent companies such as Epic Games (Fortnite) Ubisoft and LucasArts. Major themes explored in this book: Provides an overview of how the brain learns and processes information by distilling research findings from cognitive science and psychology research in a very accessible way. Topics covered include: neuromyths perception memory attention motivation emotion and learning. Includes numerous examples from released games of how scientific knowledge translates into game design and how to use a UX framework in game development. Describes how UX can guide developers to improve the usability and the level of engagement a game provides to its target audience by using cognitive psychology knowledge implementing human-computer interaction principles and applying the scientific method (user research). Provides a practical definition of UX specifically applied to games with a unique framework. Defines the most relevant pillars for good usability (ease of use) and good engage-ability (the ability of the game to be fun and engaging) translated into a practical checklist. Covers design thinking game user research game analytics and UX strategy at both a project and studio level. This book is a practical tool that any professional game developer or student can use right away and includes the most complete overview of UX in games existing today. | The Gamer's Brain How Neuroscience and UX Can Impact Video Game Design

GBP 48.99
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Numerical Modeling of COVID-19 Neurological Effects ODE/PDE Analysis in R

Numerical Modeling of COVID-19 Neurological Effects ODE/PDE Analysis in R

Covid-19 is primarily a respiratory disease which results in impaired oxygenation of blood. The O2-deficient blood then moves through the body and for the study in this book the focus is on the blood flowing to the brain. The dynamics of blood flow along the brain capillaries and tissue is modeled as systems of ordinary and partial differential equations (ODE/PDEs). The ODE/PDE methodology is presented through a series of examples 1. A basic one PDE model for O2 concentration in the brain capillary blood. 2. A two PDE model for O2 concentration in the brain capillary blood and in the brain tissue with O2 transport across the blood brain barrier (BBB). 3. The two model extended to three PDEs to include the brain functional neuron cell density. Cognitive impairment could result from reduced neuron cell density in time and space (in the brain) that follows from lowered O2 concentration (hypoxia). The computer-based implementation of the example models is presented through routines coded (programmed) in R a quality open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized e. g. no theorems and proofs. Rather the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The PDE analysis is based on the method of lines (MOL) an established general algorithm for PDEs implemented with finite differences. The routines are available from a download link so that the example models can be executed without having to first study numerical methods and computer coding. The routines can then be applied to variations and extensions of the blood/brain hypoxia models such as changes in the ODE/PDE parameters (constants) and form of the model equations. | Numerical Modeling of COVID-19 Neurological Effects ODE/PDE Analysis in R

GBP 82.99
1

EEG/ERP Analysis Methods and Applications

EEG/ERP Analysis Methods and Applications

Changes in the neurological functions of the human brain are often a precursor to numerous degenerative diseases. Advanced EEG systems and other monitoring systems used in preventive diagnostic procedures incorporate innovative features for brain monitoring functions such as real-time automated signal processing techniques and sophisticated amplifiers. Highlighting the US Europe Australia New Zealand Japan Korea China and many other areas EEG/ERP Analysis: Methods and Applications examines how researchers from various disciplines have started to work in the field of brain science and explains the different techniques used for processing EEG/ERP data. Engineers can learn more about the clinical applications while clinicians and biomedical scientists can familiarize themselves with the technical aspects and theoretical approaches. This book explores the recent advances involved in EEG/ERP analysis for brain monitoring details successful EEG and ERP applications and presents the neurological aspects in a simplified way so that those with an engineering background can better design clinical instruments. It consists of 13 chapters and includes the advanced techniques used for signal enhancement source localization data fusion classification and quantitative EEG. In addition some of the chapters are contributed by neurologists and neurosurgeons providing the clinical aspects of EEG/ERP analysis. Covers a wide range of EEG/ERP applications with state-of-the-art techniques for denoising analysis and classification Examines new applications related to 3D display devices Includes MATLAB® codes EEG/ERP Analysis: Methods and Applications is a resource for biomedical and neuroscience scientists who are working on neural signal processing and interpretation and biomedical engineers who are working on EEG/ERP signal analysis methods and developing clinical instrumentation. It can also assist neurosurgeons psychiatrists and postgraduate students doing research in neural engineering as well as electronic engineers in neural signal processing and instrumentation. | EEG/ERP Analysis Methods and Applications

GBP 52.99
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Radionuclide Peptide Cancer Therapy

Behavioral Neuroendocrinology

Probiotics in Mental Health

Probiotics in Mental Health

The concept that the gut and brain are intricately linked is widely accepted not just within the lay community but increasingly within scientific and therapeutic circles as well. Terms such as heartache and gut wrenching are more than mere metaphor they represent key fundamental aspects of human experience which all individuals will invariably endure from time to time. The relationship between the gut and brain is complex but fundamental to health and wellbeing. Increasing and compelling evidence supports the existence of a relationship between the health and status of the gut and the manifestation of significant psychopathology. Uniquely within the field of mental health and psychiatry the role of gut flora and probiotics in both the understanding and treatment of mental illness represents an emerging science whether the potential for therapeutic intervention through the use of probiotics offers an opportunity to determine efficacy within a coherent evidence-based model of both action and pathology or moreover offers interventions that are comparatively benign compared to the side-effect profile associated with most drugs used to treat mental illness. Probiotics in Mental Health examines the role of probiotics in a range of clinical presentations associated with significant psychopathology and facilitates a reconsideration of how mental illness may be conceptualised within a coherent gut-brain model of health and wellbeing. Under the rubric of enhancing wellbeing rather than dwelling on illness and disease this exciting new volume not only comprises the latest evidence in the field but also advocates an approach characterised by the understanding of mental disorder within an evidence-based model and the pursuit of mental health and wellbeing through the most benign of interventions.

GBP 44.99
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