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Process Chemistry in the Pharmaceutical Industry Volume 2 Challenges in an Ever Changing Climate

Process Chemistry in the Pharmaceutical Industry Volume 2 Challenges in an Ever Changing Climate

As pharmaceutical companies strive to develop safer medicines at a lower cost they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work Process Chemistry in the Pharmaceutical Industry Vol. 2: Challenges in an Ever Changing Climate explores novel applications of synthetic physical and analytical chemistry in drug discovery and development. It offers an accurate depiction of the most up-to-date process research and development methods applied to synthesis clinical trials and commercializing drug candidates. The second installment in this progressive series this volumereviews the latest breakthroughs to advance process chemistry including asymmetric synthesis crystallization morphology enzymatic intervention green chemistry macromolecules (monoclonal antibodies biological molecules polymers) enantioselectivity organometallic chemistry process analytical tools chemical engineering controls regulatory compliance and outsourcing/globalization. It explores new approaches to synthetic processes examines the latest safety methods and experiment design and suggests realistic solutions to problems encountered in manufacturing and process development. Significant topics include atom economy ease of synthesis instrumentation automization quality control cost considerations green practices and future trends. Jointly edited by the founder/president of Delphian Pharmaceuticals and the director of Chemical R&D at Pfizer this book brings together contributions byreputed scientists technologists engineers and professors from leading academic institutions such as the Imperial College UK the University of Tokyo ETH Switzerland the International University at Bermen Germany and the University of Connecticut USA and from principal pharmaceutical companies that include Merck Bristol Myers Squibb Pfizer Novartis Eli Lilly Astrazeneca and DSM. | Process Chemistry in the Pharmaceutical Industry Volume 2 Challenges in an Ever Changing Climate

GBP 44.99
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Cannabis as Medicine

Cannabis as Medicine

For hundreds of years cannabis has been used as a therapeutic medicine around the world. Cannabis was an accepted medicine during the second half of the 19th century but its use declined because single agent pain medications were advocated by physicians who demanded standardization of medicines. It was not until 1964 when the chemical structure of THC (delta 9-tetrahydrocannabinol) was elucidated and its pharmacological effects began to be understood. Numerous therapeutic effects of cannabis have been reviewed but cannabis-based medicines are still an enigma because of legal issues. Many patients could benefit from cannabinoids terpenoids and flavonoids found in Cannabis sativa L. These patients suffer from medical conditions including chronic pain chronic inflammatory diseases neurological disorders and other debilitating illnesses. As more states are legalizing medical cannabis prescribers need a reliable source which provides clinical information in a succinct format. This book focuses on the science of cannabis as an antioxidant and anti-inflammatory supplement. It discusses cannabis uses in the human body for bone health/osteoporosis; brain injury and trauma; cancer; diabetes; gastrointestinal conditions; mental health disorders; insomnia; pain; anxiety disorders; depression; migraines; eye disorders; and arthritis and inflammation. There is emphasis on using the whole plant — from root to raw leaves and flowers discussing strains extraction and analysis and use of cannabis-infused edibles. Features: Provides an understanding of the botanical and biochemistry behind cannabis as well as its use as a dietary supplement. Discusses endocannabinoid system and cannabinoid receptors. Includes information on antioxidant benefits pain receptors using cannabinoids and dosage guidelines. Presents research on cannabis treatment plans drug-cannabis interactions and dosing issues cannabis vapes edibles creams and suppositories. Multiple appendices including a glossary of cannabis vocabulary how to use cannabis products a patient guide and recipes as well as information on cannabis for pets. | Cannabis as Medicine

GBP 56.99
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The A-Z Guide to Food as Medicine Second Edition

The A-Z Guide to Food as Medicine Second Edition

Reprising The 2017 American Library Association Outstanding Academic Title award-winning A-Z Guide to Food As Medicine this new edition explores the physiological effects of more than 250 foods food groups nutrients and phytochemicals in entries that include: Definition and background information such as traditional medicinal use culinary facts and dietary intake and deficiency information Scientific findings on the physiological effects of foods food groups and food constituents Bioactive dose when known such as nutrient Dietary Reference Intakes focusing on 19-to-50-year-old individuals Safety highlights such as nutrient Tolerable Upper Intake Levels A health professional’s comprehensive nutrition handbook that includes all nutrients nutrient functions good and excellent sources of nutrients nutrient assessment and deficiency symptoms as well as summaries of foods food groups and phytochemicals. New to the Second Edition: Disease- and condition-focused Index that leads readers to foods used to manage specific conditions and diseases Focus on practical recommendations for health maintenance and disease prevention including tables insets and updated scientific findings on more than a dozen new foods Accompanying teaching aids and lesson plans available online at http://www. crcpress. com Features: Dictionary-style summaries of the physiological effects of foods food groups nutrients and phytochemicals alphabetically listed for quick access Approximately 60 B & W images of foods; informational tables and insets that define or illustrate concepts such as drug terminologies classes of phytochemicals and medicinal aspects of foods and of a plant-based diet Over 1 000 scientific references from peer-reviewed sources including The Academy of Nutrition and Dietetics Evidence Analysis Library and position statements of major health organizations | The A-Z Guide to Food as Medicine Second Edition

GBP 69.99
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Polymer Biomaterials in Solution as Interfaces and as Solids A Festschrift Honoring the 60th Birthday of Dr. Allan S. Hoffman

Seaweeds as Plant Fertilizer Agricultural Biostimulants and Animal Fodder

Phytosterols as Functional Food Components and Nutraceuticals

Ethics for Bioengineering Scientists Treating Data as Clients

Ethics for Bioengineering Scientists Treating Data as Clients

This book introduces bioengineers and students who must generate and/or report scientific data to the ethical challenges they will face in preserving the integrity of their data. It provides the perspective of reaching ethical decisions via pathways that treat data as clients to whom bioengineering scientists owe a responsibility that is an existential component of their professional identity. The initial chapters lay a historical biological and philosophical foundation for ethics as a human activity and data as a foundation of science. The middle chapters explore ethical challenges in lay engineering medical and bioengineering scientist settings. These chapters focus on micro-ethics individual behavior and cases that showcase the consequences of violating data integrity. Macro-ethics policy is dealt with in the Enrichment sections at the end of the chapters with essay problems and subjects for debates (in a classroom setting). The book can be used for individual study using links in the Enrichment sections to access cases and media presentations like PBS’ Ethics in America. The final chapters explore the impact of bioengineering science ethics on patients via medical product development its regulation by the FDA and the contribution of data integrity violation to product failure. The book was developed for advanced undergraduate and graduate students in bioengineering. It also contains much needed material that researchers and academics would find valuable (e. g. FDA survey and lab animal research justification). Introduces an approach to ethical decision making based on treating data as clients Compares the ethics of three professions; engineering medicine and bioengineering Provides five moral theories to choose from for evaluating ethical decisions and includes a procedure for applying them to moral analysis and application of the procedure to example cases. Examines core concepts like autonomy confidentiality conflict of interest and justice Explains the process of developing a medical product under FDA regulation Explores the role of lawyers and the judiciary in product development including intellectual property protection Examines a range of ethical cases from the historical Tuskegee autonomy case to the modern CRISPR-Cas9 patent case. Howard Winet PhD is an Adjunct Professor recall Orthopaedic Surgery and Bioengineering at University of California Los Angeles. | Ethics for Bioengineering Scientists Treating Data as Clients

GBP 64.99
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Cooking as a Chemical Reaction Culinary Science with Experiments

Cooking as a Chemical Reaction Culinary Science with Experiments

With this book students are able to perform experiments and then make observations that they will frequently see in the kitchen and other food preparation and processing areas and learn the science behind these phenomena. The second edition of Cooking as a Chemical Reaction: Culinary Science with Experiments features new chapters on food hygiene and safety kitchen terminology and taste pairing as well as an expanded chapter on the role of food additives in culinary transformations. The text uses experiments and experiences from the kitchen and other food preparation areas rather than theory as the basic means of explaining the scientific facts and principles behind food preparation and food processing. It engages students in their own learning process. This textbook is designed so that students can first perform certain experiments and record their observations in tables provided in the book. The book then explains the science behind their observations. Features: Experiments and recipes form the basic means of teaching culinary chemistry Features new chapters on food hygiene and safety kitchen terminology and taste pairing Employs real kitchen practices to explain the subjects Covers traditional food chemistry including water in culinary transformations protein carbohydrates fats sensorial properties Many concepts throughout the book are marked with a symbol that indicates the concept is one that they will come across frequently not just in this text but in the kitchen and other food preparation and processing areas. A second symbol precedes the scientific explanation of the observation made during the experiments in the chapter. At the end of each chapter students are presented with important points to remember more ideas to try and study questions to reinforce concepts that were presented in the chapter. The book is designed for each chapter to be read and studied in chronological order as the concepts of each chapter will reoccur in subsequent chapters. Written at the undergraduate level this book is designed for students in culinary arts nutrition dietetics food science and technology and gastronomy programs. It is intended for students with limited scientific background who are studying different aspects of food preparation and processing. | Cooking as a Chemical Reaction Culinary Science with Experiments

GBP 82.99
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Personalized Nutrition as Medical Therapy for High-Risk Diseases

Personalized Nutrition as Medical Therapy for High-Risk Diseases

Personalized nutrition involves the formulation of individualized nutritional recommendations to promote and maintain health based on an individual's genetic makeup and other unique intrinsic and extrinsic factors. Implementing personalized nutrition plans for individuals with certain diseases or who are in danger of developing health conditions could help control the onset and severity of symptoms. Personalized Nutrition as Medical Therapy for High-Risk Diseases offers a practical guide for physicians seeking to provide tailored dietary recommendations to their patients with disease treatment modulation and prevention in mind. The book focuses on the biological mechanisms of specific diseases and provides evidence for how personalized nutrition positively impacts them. It explores conditions including cardiovascular diseases hypertension hypercholesteromia diabetes obesity Crohn's disease as well as multiple pediatric renal and psychological disorders. Features:· Includes case studies that document how people respond differently towards food depending on their genetic structure and other factors. · Discusses genome wide association studies (GWIMS) to understand the interplay between genetic susceptibility and dietary interactions. · Provides users information to effectively implement personalized nutrition into practice. · Identifies possible challenges to the implementation of personalized nutritional interventions in a clinical setting. This book is for medical practitioners and will also appeal to researchers and students.

GBP 44.99
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Controls and Automation for Facilities Managers Efficient DDC Systems Implementation

Integrated Micro-Ring Photonics Principles and Applications as Slow Light Devices Soliton Generation and Optical Transmission

Integrated Micro-Ring Photonics Principles and Applications as Slow Light Devices Soliton Generation and Optical Transmission

Micro-ring resonators (MRRs) are employed to generate signals used for optical communication applications where they can be integrated in a single system. These structures are ideal candidates for very large-scale integrated (VLSI) photonic circuits since they provide a wide range of optical signal processing functions while being ultra-compact. Soliton pulses have sufficient stability for preservation of their shape and velocity. Technological progress in fields such as tunable narrow band laser systems multiple transmission and MRR systems constitute a base for the development of new transmission techniques. Controlling the speed of a light signal has many potential applications in fiber optic communication and quantum computing. The slow light effect has many important applications and is a key technology for all optical networks such as optical signal processing. Generation of slow light in MRRs is based on the nonlinear optical fibers. Slow light can be generated within the micro-ring devices which will be able to be used with the mobile telephone. Therefore the message can be kept encrypted via quantum cryptography. Thus perfect security in a mobile telephone network is plausible. This research study involves both numerical experiments and theoretical work based on MRRs for secured communication. | Integrated Micro-Ring Photonics Principles and Applications as Slow Light Devices Soliton Generation and Optical Transmission

GBP 44.99
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Photographic and Descriptive Musculoskeletal Atlas of Orangutans with notes on the attachments variations innervations function and synon

Photographic and Descriptive Musculoskeletal Atlas of Orangutans with notes on the attachments variations innervations function and synon

Orangutans together with chimpanzees and gorillas are our closest living relatives. Photographic and Descriptive Musculoskeletal Atlas of Orangutans the first photographic and descriptive musculoskeletal atlas of the genus Pongo adopts the same format as the photographic atlases of Gorilla Pan and Hylobates previously published by the same authors. These four books are part of a series of monographs that will set out the comparative and phylogenetic context of the gross anatomy and evolutionary history of the soft tissue morphology of modern humans and their closest relatives. The present atlas which includes detailed high-quality photographs of musculoskeletal structures from most anatomical regions of the body as well as textual information about the attachments innervation function and weight of the respective muscles is based on dissections of five orangutans and on an extensive review of the literature. It provides an updated review of the anatomical variations within orangutans as well as an extensive list of the synonyms used in the literature to designate the structures we discuss. It will be of interest to students teachers and researchers studying primatology comparative anatomy functional morphology zoology and physical anthropology and to medical students doctors and researchers who are curious about the origin evolution homology and variations of the musculoskeletal structures of modern humans. | Photographic and Descriptive Musculoskeletal Atlas of Orangutans with notes on the attachments variations innervations function and synon

GBP 59.99
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Photographic and Descriptive Musculoskeletal Atlas of Chimpanzees With Notes on the Attachments Variations Innervation Function and Synon

Photographic and Descriptive Musculoskeletal Atlas of Chimpanzees With Notes on the Attachments Variations Innervation Function and Synon

Chimpanzees including common chimpanzees and bonobos are our closest living relatives. This book which is the first photographic and descriptive musculoskeletal atlas of the genus Pan adopts the same format as the photographic atlases of Gorilla and Hylobates previously published by the same authors. These three books are part of a series of monographs that will set out the comparative and phylogenetic context of the gross anatomy and evolutionary history of the soft tissue morphology of modern humans and their closest relatives. The atlas which includes detailed high-quality photographs of musculoskeletal structures from most anatomical regions of the body as well as textual information about the attachments innervation function and weight of the respective muscles is based on dissections of up to 12 chimpanzees and on an extensive review of the literature. It provides an updated review of the anatomical variations within chimpanzees as well as an extensive list of the synonyms used in the literature. The book is designed for students teachers and researchers studying primatology comparative anatomy functional morphology zoology and physical anthropology and to medical students doctors and researchers who are curious about the origin evolution homology and variations of the musculoskeletal structures of modern humans. | Photographic and Descriptive Musculoskeletal Atlas of Chimpanzees With Notes on the Attachments Variations Innervation Function and Synon

GBP 59.99
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Good Design Practices for GMP Pharmaceutical Facilities

A Learner’s Guide to Fuzzy Logic Systems Second Edition

Applied Mathematics in Hydrogeology

Cardamom The Genus Elettaria

Investigating Sexual Assault Cases

Investigating Sexual Assault Cases

Investigating Sexual Assault Cases Second Edition serves as an essential textbook for courses in investigating rape and sexual assault. As with the first edition this second edition includes the latest research and techniques in coverage of victimology offender typology investigative techniques interviewing and legal implications. This new second edition includes chapters on child victims and molestation sexual homicides as potentially staged events grooming interviewing techniques and same-sex elder and special populations as victims of sexual assault. The book fills a current void in the body of literature on the topics of rape and sex crime investigation. Many previous writings while informative do not address all the investigative processes necessary for an investigation to be thorough and complete. By providing a fresh approach to the topic the author aims to augment those writings and ultimately improving the reader’ awareness by being much more attuned to the needs of—and taking investigative cures from—the victim. Key Features: Outlines the complete investigative process for sexual assault cases from evidence collection and interviews to court and legal proceedings Addresses victims and victimology offender typology the importance of the investigative interviewing process and working with attorneys Includes new chapters on grooming sexual homicides SAFE examinations and child-specific interviewing techniques Added coverage looks at same-sex crimes crimes against men elder victims and assault of vulnerable populations In addition to being used in coursework in Forensic Science and Criminal justice programs Investigating Sexual Assault Cases Second Edition will serve as an essential reference for police detectives criminal and death investigators legal professionals sexual assault nurses and those who provide health and mental health services to populations experiencing sexual assault.

GBP 79.99
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Rehabilitation from COVID-19 An Integrated Traditional Chinese and Western Medicine Protocol

Self-Assessment for Vascular and Endovascular Specialists

Concrete Mix Design Quality Control and Specification

Concrete Mix Design Quality Control and Specification

The nature of concrete is rapidly changing and with it there are rising concerns. Thoroughly revised and updated this fourth edition of Concrete Mix Design Quality Control and Specification addresses current industry practices that provide inadequate durability and fail to eliminate problems with underperforming new concrete and defective testing. Many specifications now require additional criteria in an attempt to improve durability or other properties. This book discusses the trend towards adding performance requirements to existing prescriptive specifications. It also explores the matter of prescription versus performance specification and especially the specification of non-strength-related performance such as durability. What’s new in the Fourth Edition: Examines water-to-cement ratio as a declining criterion of quality and durability Discusses the diminishing availability of suitable natural sands and growing industry concerns regarding the environmental impact of their use Considers advances in concrete admixtures and their ever-increasing use Advocates reliability of testing as a vital feature of the shift from prescriptive to performance specifications Addresses cement replacement materials as they relate to greenhouse gas and sustainability Concrete Mix Design Quality Control and Specification explores producing designing controlling or specifying concrete and addresses issues related with sustainability and the impact of new concrete materials such as ready mixed geopolymers magnesium oxide and calcium carbonate. The text is an ideal resource for concrete technologists producers and specifiers and contractors on large projects

GBP 84.99
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Adjoint Equations and Perturbation Algorithms in Nonlinear Problems

Techniques of Crime Scene Investigation

Techniques of Crime Scene Investigation

Techniques of Crime Scene Investigation is a staple for any forensic science library and is routinely referenced by professional organizations as a study guide for certifications. It is professionally written and provides updated theoretical and practical applications using real casework. This text is a must-have for any CSI Unit or course teaching Crime Scene Investigation. – Kevin Parmelee PhD Detective (ret. ) Somerset County NJ Prosecutor’s Office Since the first English-language edition of Techniques of Crime Scene Investigation was published in 1964 the book has continued to be a seminal work in the field of forensic science serving as a foundational textbook and reference title for professionals. This Ninth Edition includes several new chapters and has been fully updated and organized to present the effective use of science and technology in support of justice. New coverage to this edition addresses the debunking of a few forensic science disciplines long thought to have been based on sound science. The book provides students crime scene investigators forensic scientists and attorneys the proper ways to examine crime scenes and collect a wide variety of physical evidence that may be encountered. While it is not possible to cover every imaginable situation this book is a comprehensive guide that details and promotes best practices and recommendations. In today’s challenging environment it is essential that law enforcement personnel thoroughly understand and meticulously comply with the forensic evidence procedures that apply to their function in the investigation process. Criminal investigations remain as complex as ever and require professionals from many disciplines to work cooperatively toward the fair and impartial delivery of justice. Practitioners and students alike need to be aware of the increased scrutiny that they will face in the judicial system. Judges are taking a more involved role than ever before as far as the evidence and testimony that they allow into their courtrooms. No longer will substandard forensic science or crime scene investigation be acceptable. Key features: Newly reorganized contents—including 4 brand new chapters—reflects a more logical flow of crime scene processes and procedures Provides an overview of the crime scene investigation process and procedures from the first officer on the scene through the adjudication of the case Includes several new cases photos and updates in technological advances in both digital evidence and DNA in particular Science and technology applied to CSI solves crimes and saves lives. Investigators prosecutors and defense attorneys must be able to use forensic tools and resources to their fullest potential and Techniques of Crime Scene Investigation serves as an invaluable resource to further this cause.

GBP 77.99
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