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Process Chemistry in the Pharmaceutical Industry Volume 2 Challenges in an Ever Changing Climate

Process Chemistry in the Pharmaceutical Industry Volume 2 Challenges in an Ever Changing Climate

As pharmaceutical companies strive to develop safer medicines at a lower cost they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work Process Chemistry in the Pharmaceutical Industry Vol. 2: Challenges in an Ever Changing Climate explores novel applications of synthetic physical and analytical chemistry in drug discovery and development. It offers an accurate depiction of the most up-to-date process research and development methods applied to synthesis clinical trials and commercializing drug candidates. The second installment in this progressive series this volumereviews the latest breakthroughs to advance process chemistry including asymmetric synthesis crystallization morphology enzymatic intervention green chemistry macromolecules (monoclonal antibodies biological molecules polymers) enantioselectivity organometallic chemistry process analytical tools chemical engineering controls regulatory compliance and outsourcing/globalization. It explores new approaches to synthetic processes examines the latest safety methods and experiment design and suggests realistic solutions to problems encountered in manufacturing and process development. Significant topics include atom economy ease of synthesis instrumentation automization quality control cost considerations green practices and future trends. Jointly edited by the founder/president of Delphian Pharmaceuticals and the director of Chemical R&D at Pfizer this book brings together contributions byreputed scientists technologists engineers and professors from leading academic institutions such as the Imperial College UK the University of Tokyo ETH Switzerland the International University at Bermen Germany and the University of Connecticut USA and from principal pharmaceutical companies that include Merck Bristol Myers Squibb Pfizer Novartis Eli Lilly Astrazeneca and DSM. | Process Chemistry in the Pharmaceutical Industry Volume 2 Challenges in an Ever Changing Climate

GBP 44.99
1

Cannabis as Medicine

Cannabis as Medicine

For hundreds of years cannabis has been used as a therapeutic medicine around the world. Cannabis was an accepted medicine during the second half of the 19th century but its use declined because single agent pain medications were advocated by physicians who demanded standardization of medicines. It was not until 1964 when the chemical structure of THC (delta 9-tetrahydrocannabinol) was elucidated and its pharmacological effects began to be understood. Numerous therapeutic effects of cannabis have been reviewed but cannabis-based medicines are still an enigma because of legal issues. Many patients could benefit from cannabinoids terpenoids and flavonoids found in Cannabis sativa L. These patients suffer from medical conditions including chronic pain chronic inflammatory diseases neurological disorders and other debilitating illnesses. As more states are legalizing medical cannabis prescribers need a reliable source which provides clinical information in a succinct format. This book focuses on the science of cannabis as an antioxidant and anti-inflammatory supplement. It discusses cannabis uses in the human body for bone health/osteoporosis; brain injury and trauma; cancer; diabetes; gastrointestinal conditions; mental health disorders; insomnia; pain; anxiety disorders; depression; migraines; eye disorders; and arthritis and inflammation. There is emphasis on using the whole plant — from root to raw leaves and flowers discussing strains extraction and analysis and use of cannabis-infused edibles. Features: Provides an understanding of the botanical and biochemistry behind cannabis as well as its use as a dietary supplement. Discusses endocannabinoid system and cannabinoid receptors. Includes information on antioxidant benefits pain receptors using cannabinoids and dosage guidelines. Presents research on cannabis treatment plans drug-cannabis interactions and dosing issues cannabis vapes edibles creams and suppositories. Multiple appendices including a glossary of cannabis vocabulary how to use cannabis products a patient guide and recipes as well as information on cannabis for pets. | Cannabis as Medicine

GBP 56.99
1

Geopolymers as Sustainable Surface Concrete Repair Materials

The A-Z Guide to Food as Medicine Second Edition

The A-Z Guide to Food as Medicine Second Edition

Reprising The 2017 American Library Association Outstanding Academic Title award-winning A-Z Guide to Food As Medicine this new edition explores the physiological effects of more than 250 foods food groups nutrients and phytochemicals in entries that include: Definition and background information such as traditional medicinal use culinary facts and dietary intake and deficiency information Scientific findings on the physiological effects of foods food groups and food constituents Bioactive dose when known such as nutrient Dietary Reference Intakes focusing on 19-to-50-year-old individuals Safety highlights such as nutrient Tolerable Upper Intake Levels A health professional’s comprehensive nutrition handbook that includes all nutrients nutrient functions good and excellent sources of nutrients nutrient assessment and deficiency symptoms as well as summaries of foods food groups and phytochemicals. New to the Second Edition: Disease- and condition-focused Index that leads readers to foods used to manage specific conditions and diseases Focus on practical recommendations for health maintenance and disease prevention including tables insets and updated scientific findings on more than a dozen new foods Accompanying teaching aids and lesson plans available online at http://www. crcpress. com Features: Dictionary-style summaries of the physiological effects of foods food groups nutrients and phytochemicals alphabetically listed for quick access Approximately 60 B & W images of foods; informational tables and insets that define or illustrate concepts such as drug terminologies classes of phytochemicals and medicinal aspects of foods and of a plant-based diet Over 1 000 scientific references from peer-reviewed sources including The Academy of Nutrition and Dietetics Evidence Analysis Library and position statements of major health organizations | The A-Z Guide to Food as Medicine Second Edition

GBP 69.99
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Tea as a Food Ingredient Properties Processing and Health Aspects

Tea as a Food Ingredient Properties Processing and Health Aspects

Tea is one of the most widely consumed beverages worldwide and tea extract has been used in a variety of food products including beverages bread cakes ice-cream wine biscuits dehydrated fruits and various meat and dairy products. In recent years there is growing consumer interest in the tea extract supplemented products. Tea as a Food Ingredient: Properties Processing and Health Aspects provides extensive scientific information on the properties of tea foods chemical properties formulations and tea as ingredient to develop new health foods. It describes tea food production chemical and physical properties sensory quality processing technology and health benefits. Early chapters present information relating to scientific studies on the health benefits of tea and the latter chapters focus on introducing tea products into foods which is the major focus of the entire book. Key Features: Covers broad areas such as chemical properties bioactive components and health benefits of tea-based foods Focuses on chemical properties of tea foods processing technologies functional food products and health benefits Explains how the addition of tea extract changes the properties of food and consumer sensory perception This book presents current and sound scientific knowledge on the nutritional value and health benefit of the different tea-based food products and will be beneficial for food science professionals as well as anyone with an interest in tea as a food ingredient and the benefits it can provide. | Tea as a Food Ingredient Properties Processing and Health Aspects

GBP 170.00
1

Polymer Biomaterials in Solution as Interfaces and as Solids A Festschrift Honoring the 60th Birthday of Dr. Allan S. Hoffman

Seaweeds as Plant Fertilizer Agricultural Biostimulants and Animal Fodder

Phytosterols as Functional Food Components and Nutraceuticals

Essential Oils as Antimicrobial Agents in Food Preservation

Essential Oils as Antimicrobial Agents in Food Preservation

Perishable products such as fruits and vegetables account for the largest proportion of food loss due to their short shelf life especially in the absence of proper storage facilities which requires sustainable universal and convenient preservation technology. The existing methods to prolong the shelf life of food mainly include adding preservatives irradiation cold storage heat treatment and controlled atmosphere storage. But with disadvantages in irradiation cold storage heat treatment and controlled atmosphere storage chemical synthetic preservatives are still the main means to control food corruption. As the food industry responds to the increasing consumer demand for green safe and sustainable products it is reformulating new products to replace chemical synthetic food additives. Essential Oils as Antimicrobial Agents in Food Preservation provides a comprehensive introduction to the antimicrobial activity of plant essential oils and their application strategies in food preservation. It is aimed at food microbiology experts food preservation experts food safety experts food technicians and students. Features: Summarizes the application strategy and safety of essential oil in the field of food preservation Describes the synergistic antibacterial effect of essential oil and antimicrobial agents Explains the action mechanism of essential oil as antimicrobial agent against foodborne fungi foodborne bacteria viruses and insects Analyzes the antimicrobial activity of essential oil in gas phase The book discusses how as a natural antimicrobial and antioxidant essential oil has great potential to be used in the food industry to combat the growth of foodborne pathogens and spoilage microorganisms. But because the essential oil itself has obvious smell and is sensitive to light and heat it cannot be directly added to the food matrix and thus the application strategies presented in this book explain how to alleviate those issues.

GBP 150.00
1

Natural Products Alternate Therapeutic as Quorum Sensing (QS) Inhibitors

Natural Products Alternate Therapeutic as Quorum Sensing (QS) Inhibitors

Microbial biofilm plays an important role in the life cycle of microorganisms surviving in diverse and harsh environments such as extremes of temperatures pH salinity nutrient scarcity etc. Biofilm formation is a survival strategy adopted by microorganisms allowing colonization in new niches by dispersal of microbes from the microbial clusters embedded within an outer polymer layer produced by the microorganism itself. This layer comprises of extracellular polymeric substances (EPS) that helps the indwelling microbes to grow and divide in a protected environment against invaders like antimicrobial agents surfactant biocides and phagocytic cells of host organisms. Thus EPS matrix prevents the penetration of antimicrobials thereby allowing the indwelling microbes to survive and give rise to antimicrobial resistance posing threat to human health. The present book highlights a detailed analysis of the mechanism of biofilm formation in both Gram positive and Gram-negative bacteria and the role of quorum sensing signaling mechanism in the genetic regulation pathway. The book titled Natural Products: Alternative therapeutics as Quorum Sensing (QS) inhibitors provides a detailed and systematic review of mechanism of quorum sensing in both Gram positive and Gram-negative bacteria and alternative pharmacological developments as a potent solution to the rise of antimicrobial resistance during biofilm formation. Features: A systematic overview of the mechanism of quorum sensing in the development of microbial biofilms Biofilm formation and its role in the emergence of antimicrobial resistance Recent pharmacological development of antibiofilm remedies involving biogenic compounds This book serves as a reference book for researchers investigating the progression of events during microbial biofilm formation starting from the genetic cascade regulating quorum sensing to secretion of autoinducers and design of safer methodologies for the successful eradication of microbial biofilm. It may also be used as a textbook for a undergraduate level course in microbiology or microbial biotechnology. | Natural Products Alternate Therapeutic as Quorum Sensing (QS) Inhibitors

GBP 110.00
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Ethics for Bioengineering Scientists Treating Data as Clients

Ethics for Bioengineering Scientists Treating Data as Clients

This book introduces bioengineers and students who must generate and/or report scientific data to the ethical challenges they will face in preserving the integrity of their data. It provides the perspective of reaching ethical decisions via pathways that treat data as clients to whom bioengineering scientists owe a responsibility that is an existential component of their professional identity. The initial chapters lay a historical biological and philosophical foundation for ethics as a human activity and data as a foundation of science. The middle chapters explore ethical challenges in lay engineering medical and bioengineering scientist settings. These chapters focus on micro-ethics individual behavior and cases that showcase the consequences of violating data integrity. Macro-ethics policy is dealt with in the Enrichment sections at the end of the chapters with essay problems and subjects for debates (in a classroom setting). The book can be used for individual study using links in the Enrichment sections to access cases and media presentations like PBS’ Ethics in America. The final chapters explore the impact of bioengineering science ethics on patients via medical product development its regulation by the FDA and the contribution of data integrity violation to product failure. The book was developed for advanced undergraduate and graduate students in bioengineering. It also contains much needed material that researchers and academics would find valuable (e. g. FDA survey and lab animal research justification). Introduces an approach to ethical decision making based on treating data as clients Compares the ethics of three professions; engineering medicine and bioengineering Provides five moral theories to choose from for evaluating ethical decisions and includes a procedure for applying them to moral analysis and application of the procedure to example cases. Examines core concepts like autonomy confidentiality conflict of interest and justice Explains the process of developing a medical product under FDA regulation Explores the role of lawyers and the judiciary in product development including intellectual property protection Examines a range of ethical cases from the historical Tuskegee autonomy case to the modern CRISPR-Cas9 patent case. Howard Winet PhD is an Adjunct Professor recall Orthopaedic Surgery and Bioengineering at University of California Los Angeles. | Ethics for Bioengineering Scientists Treating Data as Clients

GBP 64.99
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Plants as Medicine and Aromatics Pharmacognosy Ecology and Conservation

Plants as Medicine and Aromatics Pharmacognosy Ecology and Conservation

Since ancient times plants serve as a valuable source of traditional herbal medicines. Unlike modern medicines herbal medicines have consistently demonstrated health advantages including a lack of serious adverse side effects long-lasting curative impacts and overall cost-effectiveness. Even today with various modern pharmaceutical medicines commonly available plant-based medicines and aromatics are increasingly in demand throughout the health sector globally where they are used not only for the treatment of disease but also preventatively for maintaining good health. People are seeking alternatives to modern medical treatments turning to phytomedicine for primary health care. However an inadvertent consequence of this increased demand for herbal medicines has resulted in medicinal plants being threatened due to their initial small population sizes narrow distribution areas habitat specificity and increasingly destructive non-sustainable harvesting. This book critically examines and reviews the status of medicinal plants and includes several important case studies of representative plant species. It contains information on aspects concerning phytochemistry natural products cultivation conservation techniques environmental interactions and therapeutic features of medicinal aromatic plants. Features Evaluates plants as medicine and aromatics covering pharmacognosy and ecology of plants having therapeutic values. Discusses how plants can play a role in treatment of diseases and as potential therapeutics standards for maintaining good health. Presents conventional and contemporary approaches to conservation of such plants with commercial feasibility. | Plants as Medicine and Aromatics Pharmacognosy Ecology and Conservation

GBP 150.00
1

Cooking as a Chemical Reaction Culinary Science with Experiments

Cooking as a Chemical Reaction Culinary Science with Experiments

With this book students are able to perform experiments and then make observations that they will frequently see in the kitchen and other food preparation and processing areas and learn the science behind these phenomena. The second edition of Cooking as a Chemical Reaction: Culinary Science with Experiments features new chapters on food hygiene and safety kitchen terminology and taste pairing as well as an expanded chapter on the role of food additives in culinary transformations. The text uses experiments and experiences from the kitchen and other food preparation areas rather than theory as the basic means of explaining the scientific facts and principles behind food preparation and food processing. It engages students in their own learning process. This textbook is designed so that students can first perform certain experiments and record their observations in tables provided in the book. The book then explains the science behind their observations. Features: Experiments and recipes form the basic means of teaching culinary chemistry Features new chapters on food hygiene and safety kitchen terminology and taste pairing Employs real kitchen practices to explain the subjects Covers traditional food chemistry including water in culinary transformations protein carbohydrates fats sensorial properties Many concepts throughout the book are marked with a symbol that indicates the concept is one that they will come across frequently not just in this text but in the kitchen and other food preparation and processing areas. A second symbol precedes the scientific explanation of the observation made during the experiments in the chapter. At the end of each chapter students are presented with important points to remember more ideas to try and study questions to reinforce concepts that were presented in the chapter. The book is designed for each chapter to be read and studied in chronological order as the concepts of each chapter will reoccur in subsequent chapters. Written at the undergraduate level this book is designed for students in culinary arts nutrition dietetics food science and technology and gastronomy programs. It is intended for students with limited scientific background who are studying different aspects of food preparation and processing. | Cooking as a Chemical Reaction Culinary Science with Experiments

GBP 82.99
1

Metakaolin and Fly Ash as Mineral Admixtures for Concrete

Personalized Nutrition as Medical Therapy for High-Risk Diseases

Personalized Nutrition as Medical Therapy for High-Risk Diseases

Personalized nutrition involves the formulation of individualized nutritional recommendations to promote and maintain health based on an individual's genetic makeup and other unique intrinsic and extrinsic factors. Implementing personalized nutrition plans for individuals with certain diseases or who are in danger of developing health conditions could help control the onset and severity of symptoms. Personalized Nutrition as Medical Therapy for High-Risk Diseases offers a practical guide for physicians seeking to provide tailored dietary recommendations to their patients with disease treatment modulation and prevention in mind. The book focuses on the biological mechanisms of specific diseases and provides evidence for how personalized nutrition positively impacts them. It explores conditions including cardiovascular diseases hypertension hypercholesteromia diabetes obesity Crohn's disease as well as multiple pediatric renal and psychological disorders. Features:· Includes case studies that document how people respond differently towards food depending on their genetic structure and other factors. · Discusses genome wide association studies (GWIMS) to understand the interplay between genetic susceptibility and dietary interactions. · Provides users information to effectively implement personalized nutrition into practice. · Identifies possible challenges to the implementation of personalized nutritional interventions in a clinical setting. This book is for medical practitioners and will also appeal to researchers and students.

GBP 44.99
1

Controls and Automation for Facilities Managers Efficient DDC Systems Implementation

Pesticide Regulation Handbook A Guide for Users

Integrated Micro-Ring Photonics Principles and Applications as Slow Light Devices Soliton Generation and Optical Transmission

Integrated Micro-Ring Photonics Principles and Applications as Slow Light Devices Soliton Generation and Optical Transmission

Micro-ring resonators (MRRs) are employed to generate signals used for optical communication applications where they can be integrated in a single system. These structures are ideal candidates for very large-scale integrated (VLSI) photonic circuits since they provide a wide range of optical signal processing functions while being ultra-compact. Soliton pulses have sufficient stability for preservation of their shape and velocity. Technological progress in fields such as tunable narrow band laser systems multiple transmission and MRR systems constitute a base for the development of new transmission techniques. Controlling the speed of a light signal has many potential applications in fiber optic communication and quantum computing. The slow light effect has many important applications and is a key technology for all optical networks such as optical signal processing. Generation of slow light in MRRs is based on the nonlinear optical fibers. Slow light can be generated within the micro-ring devices which will be able to be used with the mobile telephone. Therefore the message can be kept encrypted via quantum cryptography. Thus perfect security in a mobile telephone network is plausible. This research study involves both numerical experiments and theoretical work based on MRRs for secured communication. | Integrated Micro-Ring Photonics Principles and Applications as Slow Light Devices Soliton Generation and Optical Transmission

GBP 44.99
1

Optimization of Biological Sulphate Reduction to Treat Inorganic Wastewaters Process Control and Potential Use of Methane as Electron Donor

Optimization of Biological Sulphate Reduction to Treat Inorganic Wastewaters Process Control and Potential Use of Methane as Electron Donor

This work investigated two different approaches to optimize biological sulphate reduction in order to develop a process control strategy to optimize the input of an electron donor and to study how to increase the feasibility of using a cheap carbon source. Feast/famine regimes applied to design the control strategy were shown to induce the accumulation of storage compounds in the sulphate reducing biomass. This study showed that delays in the response time and a high control gain can be considered as the most critical factors affecting a sulphide control strategy in bioreactors. The delays are caused by the induction of different metabolic pathways in the anaerobic sludge including the accumulation of storage products. On this basis a mathematical model was developed and validated. This can be used to develop optimal control strategies. In order to understand the microbial pathways in the anaerobic oxidation of methane coupled to sulphate reduction (AOM-SR) diverse potential electron donors and acceptors were added to in vitro incubations of an AOM-SR enrichment at high pressure. Acetate was formed in the control group probably resulting from the reduction of CO2. These results support the hypothesis that acetate may serve as an intermediate in the AOM-SR process. | Optimization of Biological Sulphate Reduction to Treat Inorganic Wastewaters Process Control and Potential Use of Methane as Electron Donor

GBP 150.00
1

Clinical Cases for the FRCA Key Topics Mapped to the RCoA Curriculum

Trauma Care Pre-Hospital Manual

Information Security Handbook