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Cellular Signal Processing An Introduction to the Molecular Mechanisms of Signal Transduction

Cellular Signal Processing An Introduction to the Molecular Mechanisms of Signal Transduction

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology biochemistry bioinformatics and pharmacology as well as medical students. The text is organized by three key topics central to signal transduction: the protein network its energy supply and its evolution. It covers all important aspects of cell signaling ranging from prokaryotic signal transduction to neuronal signaling and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes as well as content on new developments in systems biology epigenetics redox signaling and small non-coding RNA signaling. | Cellular Signal Processing An Introduction to the Molecular Mechanisms of Signal Transduction

GBP 66.99
1

Understanding Cancer An Introduction to the Biology Medicine and Societal Implications of this Disease

Understanding Cancer An Introduction to the Biology Medicine and Societal Implications of this Disease

Understanding Cancer is a brand new undergraduate textbook for students without prior training in biology that integrates an introduction to cancer medicine with descriptions of the biological processes that go wrong to cause cancer’s onset and progression. It also highlights the human side of cancer with stories of patients and loved ones touched by the disease dealing with diagnosis treatment and the prospect of death as well as the broader societal aspects of cancer and its prevention. Key discoveries that have improved our understanding of cancer are presented in sidebars. In spite of this diversity the book maintains precision and simplicity in describing what is and is not known about cancer describing the strengths and limitations of current treatments | Understanding Cancer An Introduction to the Biology Medicine and Societal Implications of this Disease

GBP 48.99
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Strelkauskas' Microbiology A Clinical Approach

Strelkauskas' Microbiology A Clinical Approach

As with the much-praised prior editions the third edition of Strelkauskas' Microbiology: A Clinical Approach remains a comprehensive introductory textbook written specifically for pre-nursing nursing and allied health students. Clinically relevant throughout it uses the theme of infection as its foundation fitting closely with the 'One Health' approach that is considered increasingly central to the effective control of zoonoses and to combatting antimicrobial resistance. The third edition has been thoroughly revised and updated to reflect the latest developments including the emergence of the SARS-CoV-2 virus and associated COVID-19 pandemic. The book is accompanied by a robust instructor ancillary package that allows educators to incorporate readily the book’s unique approach into their lectures and includes additional materials for students to supplement classroom learning and encourage and support study and self-reflection. Key Features: Student-focused with all elements carefully designed to help students engage with and understand difficult concepts and to spark and hold interest Dedicated learning skill section introduces practical strategies for improving comprehension and retention Numerous text features further support learning and teaching including chapter overviews fast facts case studies and human stories and ‘why is this important?’ highlights A variety of question-and-answer types for self-testing and reflection to support and assess basic learning to challenge students to integrate important concepts and ask students to apply what they have just learned to a specific clinical setting or problem All supported by a comprehensive suite of online resources including lecturer support material and for students interactive questions lecture notes MicroMovies and the BugParade The book is an excellent resource to guide and support inter-professional education in the health sciences and an ideal entry-point to the subject for anyone coming from another discipline and invaluable supplementary reading for medical microbiology and biomedical science students. | Strelkauskas' Microbiology A Clinical Approach

GBP 54.99
1

Developmental Neurobiology

Developmental Neurobiology

Developmental Neurobiology tells the extraordinary process of neural development by showing how the scientific discoveries were made and how the hypotheses evolved over time. Each chapter explores the specific mechanisms of development while highlighting the key experiments and methods used to make those discoveries—including descriptions of and experiments utilizing both invertebrate and vertebrate animal models. This distinctive approach provides the essential facts while strengthening the reader’s appreciation of the scientific method. Discussions of neurodevelopmental disorders and therapeutic approaches to them will captivate those interested in the more clinical aspects of the field. With its clear illustrations and easy-to-follow writing style Developmental Neurobiology presents an accessible approach to neural development for undergraduate students.

GBP 56.99
1

Plants People and Culture The Science of Ethnobotany

Plants People and Culture The Science of Ethnobotany

Is it possible that plants have shaped the very trajectory of human cultures? Using riveting stories of fieldwork in remote villages two of the world’s leading ethnobotanists argue that our past and our future are deeply intertwined with plants. Creating massive sea craft from plants indigenous shipwrights spurred the navigation of the world’s oceans. Today indigenous agricultural innovations continue to feed clothe and heal the world’s population. One out of four prescription drugs for example were discovered from plants used by traditional healers. Objects as common as baskets for winnowing or wooden boxes to store feathers were ornamented with traditional designs demonstrating the human ability to understand our environment and to perceive the cosmos. Throughout the world the human body has been used as the ultimate canvas for plant-based adornment as well as indelible design using tattoo inks. Plants also garnered religious significance both as offerings to the gods and as a doorway into the other world. Indigenous claims that plants themselves are sacred is leading to a startling reformulation of conservation. The authors argue that conservation goals can best be achieved by learning from rather than opposing indigenous peoples and their beliefs. KEY FEATURES • An engrossing narrative that invites the reader to personally engage with the relationship between plants people and culture • Full-color illustrations throughout—including many original photographs captured by the authors during fieldwork • New to this edition—Plants That Harm a chapter that examines the dangers of poisonous plants and the promise that their study holds for novel treatments for some of our most serious diseases including Alzheimer’s and substance addiction • Additional readings at the end of each chapter to encourage further exploration • Boxed features on selected topics that offer further insight • Provocative questions to facilitate group discussion Designed for the college classroom as well as for lay readers this update of Plants People and Culture entices the reader with firsthand stories of fieldwork spectacular illustrations and a deep respect for both indigenous peoples and the earth’s natural heritage. | Plants People and Culture The Science of Ethnobotany

GBP 42.99
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Biology for the Health Sciences Mechanisms of Disease

Biology for the Health Sciences Mechanisms of Disease

Biology is central to our understanding of health and disease and to the development of effective treatments and thus it is critical that health professionals have a solid grounding and knowledge comfort in the pathogenesis and mechanisms of disease processes. This innovative new textbook draws these topics together providing an accessible introduction across four central disciplines - basic biology biotechnology non-infectious disease and infectious disease. Key Features: Provides students of biology and those going into health care professions with a strong foundation to understand the pathogenesis of disease at the molecular and cellular level Focuses on the etiology and pathophysiology of the major human diseases by body system including diabetes and nutritional disorders cardiovascular disease neurodegenerative diseases and cancer aligned to medicine and health science course structure Covers mechanisms of infectious disease transmission as well as disease pathophysiology and considers the impact of antibiotic resistance Reviews the applications of biotechnology and genomics to human health in diagnosis and treatment as well as to our understanding of disease and disease surveillance Each chapter contains a mini glossary of key terms and associated definitions and review questions allow students to assess how much of the chapter they have understood Digital resources accompany the textbook such as interactive quizzes for students to engage with and figure slides of the book's illustrations that instructors can use in lectures Enhanced throughout with plentiful illustrations Biology for the Health Sciences is an essential companion for any student of the health sciences and for biological science students studying the causes of disease as part of a wider course. | Biology for the Health Sciences Mechanisms of Disease

GBP 49.99
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Cell Boundaries How Membranes and Their Proteins Work

Cell Boundaries How Membranes and Their Proteins Work

The central themes of Cell Boundaries concern the structural and organizational principles underlying cell membranes and how these principles enable function. By building a biological and biophysical foundation for understanding the organization of lipids in bilayers and the folding assembly stability and function of membrane proteins the book aims to broaden the knowledge of bioscience students to include the basic physics and physical chemistry that inform us about membranes. In doing so it is hoped that physics students will find familiar territory that will lead them to an interest in biology. Our progress toward understanding membranes and membrane proteins depends strongly upon the concerted use of both biology and physics. It is important for students to know not only what we know but how we have come to know it so Cell Boundaries endeavours to bring out the history behind the central discoveries especially in the early chapters where the foundation is laid for later chapters. Science is far more interesting if as students we can appreciate and share in the adventures—and misadventures—of discovering new scientific knowledge. Cell Boundaries was written with advanced undergraduates and beginning graduate students in the biological and physical sciences in mind though this textbook will likely have appeal to researchers and other academics as well. Highlights the history of important central discoveries Early chapters lay the foundation for later chapters to build on so knowledge is amassed High-quality line diagrams illustrate key concepts and illuminate molecular mechanisms Box features and spreads expand on topics in main text including histories of discoveries special techniques and applications | Cell Boundaries How Membranes and Their Proteins Work

GBP 82.99
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A First Course in Systems Biology

A First Course in Systems Biology

A First Course in Systems Biology is an introduction for advanced undergraduate and graduate students to the growing field of systems biology. Its main focus is the development of computational models and their applications to diverse biological systems. The book begins with the fundamentals of modeling then reviews features of the molecular inventories that bring biological systems to life and discusses case studies that represent some of the frontiers in systems biology and synthetic biology. In this way it provides the reader with a comprehensive background and access to methods for executing standard systems biology tasks understanding the modern literature and launching into specialized courses or projects that address biological questions using theoretical and computational means. New topics in this edition include: default modules for model design limit cycles and chaos parameter estimation in Excel model representations of gene regulation through transcription factors derivation of the Michaelis-Menten rate law from the original conceptual model different types of inhibition hysteresis a model of differentiation system adaptation to persistent signals nonlinear nullclines PBPK models and elementary modes. The format is a combination of instructional text and references to primary literature complemented by sets of small-scale exercises that enable hands-on experience and large-scale often open-ended questions for further reflection.

GBP 82.99
1

Principles of Neurobiology

Principles of Neurobiology

Principles of Neurobiology Second Edition presents the major concepts of neuroscience with an emphasis on how we know what we know. The text is organized around a series of key experiments to illustrate how scientific progress is made and helps upper-level undergraduate and graduate students discover the relevant primary literature. Written by a single author in a clear and consistent writing style each topic builds in complexity from electrophysiology to molecular genetics to systems level in a highly integrative approach. Students can fully engage with the content via thematically linked chapters and will be able to read the book in its entirety in a semester-long course. Principles of Neurobiology is accompanied by a rich package of online student and instructor resources including animations figures in PowerPoint and a Question Bank for adopting instructors.

GBP 66.99
1

Human Molecular Genetics

Human Molecular Genetics

Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics genomics and cell biology. Maintaining the features that have made previous editions so popular this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized coverage of newer DNA sequencing technologies has been expanded and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS functional genomics stem cells and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation. Key features: Fully integrated approach to the molecular aspects of human genetics genomics and cell biology Accessible text is supported and enhanced throughout by superb artwork illustrating the key concepts and mechanisms Summary boxes at the end of each chapter provide clear learning points Annotated further reading helps readers navigate the wealth of additional information in this complex subject and provides direction for further study Reorganized into five sections for improved access to related topics Also new to this edition – brand new chapter on evolution and anthropology from the authors of the highly acclaimed Human Evolutionary Genetics A proven and popular textbook for upper-level undergraduates and graduate students the new edition of Human Molecular Genetics remains the ‘go-to’ book for those studying human molecular genetics or genomics courses around the world.

GBP 74.99
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Bacterial Genetics and Genomics

Bacterial Genetics and Genomics

Our understanding of bacterial genetics has progressed as the genomics field has advanced. Genetics and genomics complement and influence each other; they are inseparable. Under the novel insights from genetics and genomics once-believed borders in biology start to fade: biological knowledge of the bacterial world is being viewed under a new light and concepts are being redefined. Species are difficult to delimit and relationships within and between groups of bacteria – the whole concept of a tree of life – is hotly debated when dealing with bacteria. The DNA within bacterial cells contains a variety of features and signals that influence the diversity of the microbial world. This text assumes readers have some knowledge of genetics and microbiology but acknowledges that it can be varied. Therefore the book includes all of the information that readers need to know in order to understand the more advanced material in the book. | Bacterial Genetics and Genomics

GBP 66.99
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Plant Pathology

Plant Pathology

Plant Pathology explores the topic of plant pathology and aligns classic studies and knowledge in the topic with the current state of research in an accessible format. The text is supported by summary tables of key information and where appropriate schematic diagrams to reinforce difficult concepts such as the process of disease infection cell-to-cell recognition and plant breeding mechanisms used to develop resistant cultivars. The compendium of diseases focuses on important and major economic disease organisms from a number of crop and ornamental plants including a dedicated section on fruit crops. The compendium is supported by original photographs photomicrographs and electron micrographs of key pathogens and the development of structures such as the haustoria and the hypha and show processes of cellular degradation. The section on applied disease management contains short case studies highlighting key disease organisms affecting the crops of a range of growers illustrating the environment disease symptoms and control strategies these growers are currently using to mitigate loss of production.

GBP 51.99
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Plant Ecology and Conservation

Plant Ecology and Conservation

Plant Ecology & Conservation is an introduction to the world of plant ecology. It includes the main areas of current research including ideas about plant populations nutrition and plant community ecology and has a particular emphasis on the interactions of plants with animals fungi and microorganisms whose important is being increasingly demonstrated. With the world’s environmental problems having such a high profile the book focusses on the human impact on the world’s plant species. Conservation of the terrestrial world starts with plants as they form the basis of all ecosystems on land. We can only understand how best to conserve the world’s biodiversity with an understanding of the central role of plant ecology. This theme runs throughout with numerous examples of the disruption of ecosystems by human activity emphasising the connection between plant ecology and conservation. Key Features: Boxes present case studies important statistics and interesting asides Full-colour photos depict key species and habitats and superb line drawings illustrate many concepts Important data are presented in Tables and Figures throughout Each chapter has Key Concepts and review questions to test a reader’s grasp of the content Key References and Further Reading are given for each chapter to point the reader towards the most important and influential literature Jargon is kept to a minimum and a full Glossary of all technical terms is presented The book is aimed primarily at undergraduate and graduate students in any aspect of ecology or plant science. It should also appeal to anyone interested in how plants function and are concerned about what is needed for the conservation of the world’s ecosystems.

GBP 44.99
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John Henry Newman: Theology &

John Henry Newman: Theology &

This collection of papers grew out of a concern of several at Creighton University for the perduring nature of the thought of John Henry Cardinal Newman. Although Cardinal Newman died some one hundred years ago his influence on today’s thinking is still strong. Like Sir Thomas More with his Utopia Newman put forward an ideal of society and life which has a recognizable relation to the lasting possibilities open to humankind. First published in 1992. Routledge is an imprint of Taylor & Francis an informa company. | John Henry Newman: Theology &

GBP 42.99
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DNA Repair and Replication Mechanisms and Clinical Significance

DNA Repair and Replication Mechanisms and Clinical Significance

DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes causes of damage and methods of repair | DNA Repair and Replication Mechanisms and Clinical Significance

GBP 77.99
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Protein Actions Principles and Modeling

Protein Actions Principles and Modeling

Protein Actions: Principles and Modeling is aimed at graduates advanced undergraduates and any professional who seeks an introduction to the biological chemical and physical properties of proteins. Broadly accessible to biophysicists and biochemists it will be particularly useful to student and professional structural biologists and molecular biophysicists bioinformaticians and computational biologists biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics energetics and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science. | Protein Actions Principles and Modeling

GBP 99.99
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Fields Forces and Flows in Biological Systems

Fields Forces and Flows in Biological Systems

Fields Forces and Flows in Biological Systems describes the fundamental driving forces for mass transport electric current and fluid flow as they apply to the biology and biophysics of molecules cells tissues and organs. Basic mathematical and engineering tools are presented in the context of biology and physiology. The chapters are structured in a framework that moves across length scales from molecules to membranes to tissues. Examples throughout the text deal with applications involving specific biological tissues cells and macromolecules. In addition a variety of applications focus on sensors actuators diagnostics and microphysical measurement devices (e. g. bioMEMs/NEMs microfluidic devices) in which transport and electrokinetic interactions are critical. This textbook is written for advanced undergraduate and graduate students in biological and biomedical engineering and will be a valuable resource for interdisciplinary researchers including biophysicists physical chemists materials scientists and chemical electrical and mechanical engineers seeking a common language on the subject.

GBP 59.99
1

Transcription Factors

Transcription Factors

Transcription factors are important in regulating gene expression and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes and factors that control transcription in eukaryotic cells. It examines the regulatory systems that modulate gene expression in all cells a s well as the more specialized systems that regulate localized gene expression throughout the mammalian organism. Transcription Factors updates classical knowledge with recent advances to provide a full and comprehensive coverage of the field for postgraduates and researchers in molecular biology involved in the study of gene regulation.

GBP 59.99
1

Stem Cells Biology and Application

Stem Cells Biology and Application

Stem cell science encompassing basic biology to practical application is both vast and diverse. A full appreciation of it requires an understanding of cell and molecular biology tissue structure and physiology the practicalities of tissue engineering and bioprocessing and the pathways to clinical implementation—including the ethical and regulatory imperatives that our society requires us to address. Expectation and debate have been driven by the allure of regenerative medicine using stem cells as a source of replacements for damaged or aged tissues. The potential of stem cell application goes far beyond this. Highly innovative uses of stem cells are emerging as possible therapies for cancers treating acute damage in conditions such as stroke and myocardial infarction and resolving a whole range of diseases. Stem Cells: Biology and Application presents the basic concepts underlying the fast-moving science of stem cell biology. This textbook is written for an advanced stem cell biology course. The target audience includes senior undergraduates first year graduate students and practitioners in molecular biology biology and biomedical engineering. Stem Cells provides a comprehensive understanding of these unique cells highlighting key areas of research associated controversies case studies technologies and pioneers in the field. | Stem Cells Biology and Application

GBP 66.99
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Biology of Aging

Biology of Aging

Biology of Aging Second Edition presents the biological principles that have led to a new understanding of the causes of aging and describes how these basic principles help one to understand the human experience of biological aging longevity and age-related disease. Intended for undergraduate biology students it describes how the rate of biological aging is measured; explores the mechanisms underlying cellular aging; discusses the genetic pathways that affect longevity in various organisms; outlines the normal age-related changes and the functional decline that occurs in physiological systems over the lifespan; and considers the implications of modulating the rate of aging and longevity. The book also includes end-of-chapter discussion questions to help students assess their knowledge of the material. Roger McDonald received his Ph. D. from the University of Southern California and is Professor Emeritus in the Department of Nutrition at the University of California Davis. Dr. McDonald’s research focused on mechanisms of cellular aging and the interaction between nutrition and aging. His research addressed two key topics in the field: the relationship between dietary restriction and lifespan and the effect of aging on circadian rhythms and hypothalamic regulation. You can contact Dr. McDonald at rbmcdonald@ucdavis. edu. Related Titles Ahmad S. I. ed. Aging: Exploring a Complex Phenomenon (ISBN 978-1-1381-9697-1) Moody H. R. & J. Sasser. Gerontology: The Basics (ISBN 978-1-1387-7582-4) Timiras P. S. Physiological Basis of Aging and Geriatrics (ISBN 978-0-8493-7305-3)

GBP 56.99
1

Molecular Biology Structure and Dynamics of Genomes and Proteomes

Molecular Biology Structure and Dynamics of Genomes and Proteomes

Molecular Biology: Structure and Dynamics of Genomes and Proteomes second edition illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA RNA and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous yet still concise summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system Coronaviruses – structure genome vaccine and drug development and newly recognized mechanisms for transcription termination. The text is written for advanced undergraduate or graduate-level courses in molecular biology. Key Features Highlights the experimental basis of important discoveries in molecular biology Thoroughly updated with new information on gene editing tools viruses and transcription mechanisms termination and antisense Provides learning objectives for each chapter Includes a list of relevant videos from the Internet about the topics covered in the chapter | Molecular Biology Structure and Dynamics of Genomes and Proteomes

GBP 64.99
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Case Studies in Veterinary Immunology

Case Studies in Veterinary Immunology

Case Studies in Veterinary Immunology presents basic immunological concepts in the context of actual cases seen in clinics. It is intended for veterinary medicine students interns residents and veterinarians and serves as a valuable supplement and companion to a variety of core immunology textbooks and courses. The book includes cases describing primary immune system defects secondary immune system defects and hypersensitivity and autoimmune disorders as well as dysproteinemias and lymphoid neoplasia. Drawing on the successful approach of Geha’s Case Studies in Immunology each representative case is preceded by a discussion of the principles underlying that specific immunological mechanism. The case itself includes the presenting complaint (signalment) physical examination findings pertinent diagnostic laboratory data diagnosis and treatment options. In those instances in which a specific disorder occurs in both animals and humans the differences and similarities in the immunological mechanisms and manifestations of the disease are explored. End of case questions highlight important concepts and serve as a review aid for students. Details on standard vaccines and vaccination schedules as well as descriptions of the types of assays used for evaluation of the immune system are included as appendices.

GBP 42.99
1

Molecular and Cellular Biology of Viruses

Molecular and Cellular Biology of Viruses

Viruses interact with host cells in ways that uniquely reveal a great deal about general aspects of molecular and cellular structure and function. Molecular and Cellular Biology of Viruses leads students on an exploration of viruses by supporting engaging and interactive learning. All the major classes of viruses are covered with separate chapters for their replication and expression strategies and chapters for mechanisms such as attachment that are independent of the virus genome type. Specific cases drawn from primary literature foster student engagement. End-of-chapter questions focus on analysis and interpretation with answers being given at the back of the book. Examples come from the most-studied and medically important viruses such as HIV influenza and poliovirus. Plant viruses and bacteriophages are also included. There are chapters on the overall effect of viral infection on the host cell. Coverage of the immune system is focused on the interplay between host defenses and viruses with a separate chapter on medical applications such as anti-viral drugs and vaccine development. The final chapter is on virus diversity and evolution incorporating contemporary insights from metagenomic research. Key selling feature: Readable but rigorous coverage of the molecular and cellular biology of viruses Molecular mechanisms of all major groups including plant viruses and bacteriophages illustrated by example Host-pathogen interactions at the cellular and molecular level emphasized throughout Medical implications and consequences included Quality illustrations available to instructors Extensive questions and answers for each chapter

GBP 69.99
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