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Instrumentation for Trace Organic Monitoring

Practical Holography

Routledge Handbook of Chinese Business and Management

The Routledge Companion to Theatre and Young People

Routledge Handbook of Violent Extremism and Resilience

Routledge Handbook of Violent Extremism and Resilience

At a time of great global uncertainty and instability communities face fracturing from the increasing influence of extremist movements hostile to democratic and multicultural norms. Europe and the West have grown increasingly polarised in recent years beset with financial crises political instability the rise of malicious actors and irregular violence and new forms of media and social media. These factors have enabled the spread of new forms of extremism and suggest a growing need for a response sensitive to inequalities and divisions in wider society – a task made even more urgent by the COVID- 19 pandemic. The Routledge Handbook of Violent Extremism and Resilience brings together research conducted throughout Europe and the world to analyse various articulations of violent extremism and consider the impact that such groups and networks have had on the wellbeing of communities and societies. It examines different theories factors and national case studies of extremism polarisation and societal fragmentation drilling deep into national examples to map trends across Europe North America and Australasia to provide regional and state-level comparative analysis. It also offers a thorough exploration of resilience – a recent addition to counterextremism policy and practice – to consider how it has come to play this increasingly central role in Preventing and Countering Violent Extremism (P/ CVE) the limitations and opportunities of such approaches and how it could be shared developed problematised and deployed in response to violence and polarisation. The Handbook details new trends in both violent extremism and counter-extremism response within this increasingly fractured global context. It critically explores the latest theories of community violence extremism polarisation and resilience mapping them across case study countries. In doing so it presents new findings for students researchers practitioners and policymakers seeking to understand these new patterns of polarisation and extremism and develop community-driven responses.

GBP 205.00
1

Organelle and Molecular Targeting

Organelle and Molecular Targeting

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines such as the mRNA vaccines encoding the viral spike protein demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA DNA and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines reducing the required dose and therefore the biomanufacturing demand. Likewise improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies cancer neurodegeneration progerias diabetes and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status demand and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students scientists and clinicians contributing to modern medicine.

GBP 200.00
1