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Handbook of Low-Level Laser Therapy

Handbook of Low-Level Laser Therapy

Low-Level Laser Therapy (LLLT) also known as photobiomodulation is almost 50 years old and recently has been getting increasing acceptance from the scientific medical and veterinary communities. Discoveries are constantly being made about the cellular and molecular mechanisms of action the range of diseases that can be treated is also rising and home use LED devices are becoming common. This book compiles cutting-edge contributions from the world’s leading experts in Photobiomodulation and LLLT. Chapters cover general concepts mechanisms of action in vitro studies pre-clinical animal studies veterinary applications and a wide range of clinical topics. Edited by Michael Hamblin from Massachusetts General Hospital and Harvard Medical School aided by two prominent researchers (Marcelo Sousa and Tanupriya Agrawal) this book will appeal to anyone involved in the basic science translational aspects and clinical applications of LLLT. | Handbook of Low-Level Laser Therapy

GBP 335.00
1

The Routledge International Handbook of Couple and Family Therapy

The Routledge International Handbook of Couple and Family Therapy

The Routledge International Handbook of Couple and Family Therapy is a comprehensive text that promotes innovative frameworks and interventions in couple and family therapy from a cross cultural perspective. A diverse range of international contributors explore the role that demography regionality cultural and political crises and policy have on the issues faced by couples and families. Collectively the chapters articulate unique ideas in conceptualizing the needs of families with international backgrounds adapting the current models and frameworks to work with this population most effectively. The text is split into four sections covering: personal voices and philosophical perspectives theory and models specific applications with international populations and emerging perspectives. This handbook is essential for individual practitioners researchers psychotherapists and related mental health professionals as well as academics with an interest in working with couples and families.

GBP 205.00
1

Sex-Offender Therapy A How-To Workbook for Therapists Treating Sexually Aggressive Adults Adolescents and Children

Sex-Offender Therapy A How-To Workbook for Therapists Treating Sexually Aggressive Adults Adolescents and Children

Groundbreaking information for treating sex offenders Sexual abuse sexual addiction and sexual offending have become a significant clinical problem. Successfully treating these disorders is the first step toward preventing future victims. Sex-Offender Therapy is a practical workbook for clinicians who deal with sexually aggressive adults adolescents and children. This invaluable professional resource focuses on how to treat patients male and female impaired by sexual addiction sexual disorders sex offending and other sexual misconduct behaviors. Designed as an accessible step-by-step guide Sex-Offender Therapy features case studies work exercises and clinical suggestions that help to walk the reader through a sexual disorders program. With a wealth of therapeutic interventions as well as information on polygraph testing and the FDA-approved plethysmograph this unique text breaks new ground. Additionally this detailed volume not only presents clinical definitions of all the sexual disorders but goes beyond patient features and evaluation to look at useable concrete methods for lasting treatment. Topics discussed in Sex-Offender Therapy include: problems stress and boundary setting transference and countertransference sexual recovery therapy and its techniques acknowledgement and responsibility the stand-up presentation and victim empathy cycles of offending using the four phases as a relapse prevention format working with the difficult offender trauma in adult adolescent and child offenders the cost of offending antisocial disordered patients triggers clinical interviewing and report writing adult and juvenile psychosexual evaluations polygraph testing treatment of sexually aggressive youths defense behaviors group therapy and many more! Informative practical and user-fr | Sex-Offender Therapy A How-To Workbook for Therapists Treating Sexually Aggressive Adults Adolescents and Children

GBP 180.00
1

Favorite Counseling and Therapy Techniques

Favorite Counseling and Therapy Techniques

In the new edition of this highly popular book Howard Rosenthal once again brings together a group of prominent therapists who share their insightful pioneering and favorite therapeutic techniques. These therapists include such well-known figures as Albert Ellis Arnold Lazarus William Glasser Raymond Corsini and Allen E. Ivey. Many of the classic entries in the previous edition are once again included some unaltered and others updated while several new chapters have been added to reflect the newest advancements in the counseling field. For practitioners wondering what methods to use when working with clients and what they can prescribe for them between sessions or for those who simply are interested in gaining insight into the thoughts and minds of such eminent therapists the more than 50 entries in this text are sure to be both highly useful and exciting reads. | Favorite Counseling and Therapy Techniques

GBP 180.00
1

Heating and Cooling with Ground-Source Heat Pumps in Moderate and Cold Climates Two-Volume Set

Heating and Cooling with Ground-Source Heat Pumps in Moderate and Cold Climates Two-Volume Set

Heating and Cooling with Ground-Source Heat Pumps in Moderate and Cold Climates Two-Volume Set focuses on the use of very low-temperature geothermal energy for heating and cooling residential institutional and industrial buildings and aims to increase the design community’s awareness and knowledge of the benefits design and installation requirements of commercial/institutional building ground-source heat pumps (GSHP). This set helps readers assess applicability select a GSHP system type and estimate building thermal load to ensure proper size for ground-source subsystems appropriate brine and groundwater flow rates and apt design of building closed-loops with distributed or central geothermal heat pumps. The first volume addresses fundamentals and design principles of vertical and horizontal indirect and direct expansion closed-loop as well as ground- and surface-water ground-source heat pump systems. It explains the thermodynamic aspects of mechanical and thermochemical compression cycles of geothermal heat pumps as well as the energetic economic and environmental aspects associated with the use of ground-source heat pump systems for heating and cooling residential and commercial/institutional buildings in moderate and cold climates. The second volume focuses on applications and cases studies of ground-source heat pumps in moderate and cold climates. It details technical aspects as well as the most common and uncommon application fields of basic system configurations. The principles of system integrations and applications in moderate and cold climates are also presented each followed by case studies. This comprehensive work is aimed at designers of HVAC systems as well as geological mechanical and chemical engineers implementing environmentally-friendly heating and cooling technologies for buildings.

GBP 250.00
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The Collected Papers of Bertrand Russell Volume 26 Cold War Fears and Hopes 1950–52

The Collected Papers of Bertrand Russell Volume 26 Cold War Fears and Hopes 1950–52

The Collected Papers of Bertrand Russell Volume 26 covers a period of transition in Russell's political life between his orthodox and sometimes pugnacious defence of the West in the early post-war and the dissenting advocacy of nuclear disarmament and détente that started in earnest in the mid-1950s. While some of the assembled writings echo harsh prior criticism of Soviet expansionism and dictatorship others register growing qualms about the recklessness of American foreign policy and the baneful effects on civil liberties of anti-communist hysteria inside the United States. Whether continuing to push for western rearmament or highlighting in a more placatory vein the folly of the Cold War's divisions and rival fanaticisms Russell's paramount objective was avoiding a war that threatened global catastrophe. Suspended between fear and hope he expounded his evolving political concerns–and much else besides including autobiographical reflections and typically common-sense guidance for living well–in a constant flow of newspaper and magazine articles letters to editors radio broadcasts and discussions and of special note a Nobel Prize acceptance speech. Russell also completed two lecture tours of the United States (the last of many) as well as a landmark such visit to Australia. All three of these journeys and the textual record they left are examined in depth using manuscript material and unpublished correspondence from the Bertrand Russell Archives at McMaster University which is mined extensively throughout the volume. | The Collected Papers of Bertrand Russell Volume 26 Cold War Fears and Hopes 1950–52

GBP 270.00
1

Legionellosis Volume I

Legionellosis Volume I

Legionellosis is a text in two volumes that presents the modern viewpoint of the agent and the disease. It also chronicles the history of the discovery of Legionella pneumophila. Volume 1 discusses current aspects of the microbe including taxonomy morphology biochemistry and physiology. It also discusses the illness including clinical features pathology and therapy. Volume II details the laboratory diagnosis epidemiology and pathology. The contributors are amongst the most eminent scientists in their respective fields. | Legionellosis Volume I

GBP 180.00
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The Chemistry and Metabolism of 4' - Deoxypyridoxine

The Chemistry and Metabolism of 4' - Deoxypyridoxine

This review organizes the existing literature on deoxypyridoxine in order to provide additional insights for developing further work. By providing a thorough analysis of previous work with deoxypyridoxine it can be used more effectively as a tool for examining various metabolic pathways and explored further for its potential clinical use in cancer therapy immunosuppression or other areas. The book also stimulate some new insights into action of vitamin B6 itself. | The Chemistry and Metabolism of 4' - Deoxypyridoxine

GBP 180.00
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Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer β-Lactams and related compounds as antibacterials non-vitamin K oral anticoagulants for the treatment of thromboembolic diseases and the molecular mechanisms for statin pleiotropy and its clinical relevance in cardiovascular diseases. The last chapter is a review of lysosomal storage disorders with an overview of approved drugs for treating these disorders by enzyme replacement therapy. | Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

GBP 193.00
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Nanomedicine in Cancer

Nanomedicine in Cancer

This book is the first in a series compiling highly cited articles in nanomedicine recently. The series is edited by Lajos P. Balogh a prominent nanotechnology researcher and journal editor. The first book content is about nanotechnology in cancer research. It also includes a wide variety of must-know topics that will appeal to any researcher involved in nanomedicine macromolecular science cancer therapy and drug delivery research. These 31 articles collected here have already acquired more than 3500 citations (i. e. over a hundred on average) highlighting the importance and recognized professional interest of the scientists working in this field. | Nanomedicine in Cancer

GBP 347.00
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A Primer on Wavelets and Their Scientific Applications

A Primer on Wavelets and Their Scientific Applications

In the first edition of his seminal introduction to wavelets James S. Walker informed us that the potential applications for wavelets were virtually unlimited. Since that time thousands of published papers have proven him true while also necessitating the creation of a new edition of his bestselling primer. Updated and fully revised to include the latest developments this second edition of A Primer on Wavelets and Their Scientific Applications guides readers through the main ideas of wavelet analysis in order to develop a thorough appreciation of wavelet applications. Ingeniously relying on elementary algebra and just a smidgen of calculus Professor Walker demonstrates how the underlying ideas behind wavelet analysis can be applied to solve significant problems in audio and image processing as well in biology and medicine. Nearly twice as long as the original this new edition provides 104 worked examples and 222 exercises constituting a veritable book of review material Two sections on biorthogonal wavelets A mini-course on image compression including a tutorial on arithmetic compression Extensive material on image denoising featuring a rarely covered technique for removing isolated randomly positioned clutter Concise yet complete coverage of the fundamentals of time-frequency analysis showcasing its application to audio denoising and musical theory and synthesis An introduction to the multiresolution principle a new mathematical concept in musical theory Expanded suggestions for research projects An enhanced list of references

GBP 180.00
1

The Routledge Companion to Applied Musicology

The Routledge Companion to Applied Musicology

The Routledge Companion to Applied Musicology brings together academics artist-researchers and practitioners to provide readers with an extensive and authoritative overview of applied musicology. Once a field that addressed music’s socio-political or performative contexts applied musicology today encompasses study and practice in areas as diverse as psychology ecomusicology organology forensic musicology music therapy health and well-being and other public-oriented musicologies. These rapid advances have created a fast-changing field whose scholarship and activities tend to take place in isolation from each other. This volume addresses that shortcoming bringing together a wide-ranging survey of current approaches. Featuring 39 authors The Routledge Companion to Applied Musicology falls into five parts—Defining and Theorising Applied Musicology; Public Engagement; New Approaches and Research Methods; Representation and Inclusion; and Musicology in/for Performance—that chronicle the subject’s rich history and consider the connections that will characterise its future. The book offers an essential resource for anyone exploring applied musicology.

GBP 205.00
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Routledge International Handbook of Therapeutic Stories and Storytelling

Routledge International Handbook of Therapeutic Stories and Storytelling

The Routledge International Handbook of Therapeutic Stories and Storytelling is a unique book that explores stories from an educational community social health therapeutic and therapy perspectives acknowledging a range of diverse social and cultural views in which stories are used and written by esteemed storytellers artists therapists and academics from around the globe. The book is divided into five main sections that examine different approaches and contexts for therapeutic stories and storytelling. The collected authors explore storytelling as a response to the Covid-19 pandemic in education social and community settings and in health and therapeutic contexts. The final section offers an International Story Anthology written by co-editor Sharon Jacksties and a final story by Katja Gorečan. This book is of enormous importance to psychotherapists and related mental health professionals as well as academics storytellers teachers people working in special educational needs and all those with an interest in storytelling and its applied value.

GBP 205.00
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Handbook of Radiotherapy Physics Theory and Practice Second Edition Two Volume Set

Handbook of Radiotherapy Physics Theory and Practice Second Edition Two Volume Set

From the essential background physics and radiobiology to the latest imaging and treatment modalities the updated second edition of Handbook of Radiotherapy Physics: Theory & Practice covers all aspects of the subject. In Volume 1 Part A includes the Interaction of Radiation with Matter (charged particles and photons) and the Fundamentals of Dosimetry with an extensive section on small-field physics. Part B covers Radiobiology with increased emphasis on hypofractionation. Part C describes Equipment for Imaging and Therapy including MR-guided linear accelerators. Part D on Dose Measurement includes chapters on ionisation chambers solid-state detectors film and gels as well as a detailed description and explanation of Codes of Practice for Reference Dose Determination including detector correction factors in small fields. Part E describes the properties of Clinical (external) Beams. The various methods (or ‘algorithms’) for Computing Doses in Patients irradiated by photon electron and proton beams are described in Part F with increased emphasis on Monte-Carlo-based and grid-based deterministic algorithms. In Volume 2 Part G covers all aspects of Treatment Planning including CT- MR- and Radionuclide-based patient imaging Intensity-Modulated Photon Beams Electron and Proton Beams Stereotactic and Total Body Irradiation and the use of the dosimetric and radiobiological metrics TCP and NTCP for plan evaluation and optimisation. Quality Assurance fundamentals with application to equipment and processes are covered in Part H. Radionuclides equipment and methods for Brachytherapy and Targeted Molecular Therapy are covered in Parts I and J respectively. Finally Part K is devoted to Radiation Protection of the public staff and patients. Extensive tables of Physical Constants Photon Electron and Proton Interaction data and typical Photon Beam and Radionuclide data are given in Part L. Edited by recognised authorities in the field with individual chapters written by renowned specialists this second edition of Handbook of Radiotherapy Physics provides the essential up-to-date theoretical and practical knowledge to deliver safe and effective radiotherapy. It will be of interest to clinical and research medical physicists radiation oncologists radiation technologists PhD and Master’s students. | Handbook of Radiotherapy Physics Theory and Practice Second Edition Two Volume Set

GBP 375.00
1

Advances in Audiology and Hearing Science (2-volume set) Volume 1: Clinical Protocols and Hearing Devices Volume 2: Otoprotection Regenera

Advances in Audiology and Hearing Science (2-volume set) Volume 1: Clinical Protocols and Hearing Devices Volume 2: Otoprotection Regenera

With chapters from audiology professionals from around the world Advances in Audiology and Hearing Science-presented in two volumes—provides an abundance of valuable information on the latest technological and procedural advances in this ever-improving field. Volume 1 primarily focuses on revised clinical protocols and provides information on new research to help guide decisions and criteria regarding diagnosis management and treatment of hearing-related issues. Topics include new clinical applications such as auditory steady-state response wideband acoustic immittance otoacoustic emissions frequency following response noise exposure genomics and hearing loss and more. Volume 2 includes sections with material related to hearing devices hearing in special populations such as the children and the elderly as well chapters on the fast-growing subfields of otoprotection and regeneration including pharmacologic otoprotection stem cells and nanotechnology. Topics include early auditory development in children after cochlear implantation music therapy the effect of music on hearing health and auditory enhancement. | Advances in Audiology and Hearing Science (2-volume set) Volume 1: Clinical Protocols and Hearing Devices Volume 2: Otoprotection Regenera

GBP 308.00
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The Routledge Handbook of Religion Medicine and Health

The Routledge Handbook of Religion Medicine and Health

The relationships between religion spirituality health biomedical institutions complementary and alternative healing systems are widely discussed today. While many of these debates revolve around the biomedical legitimacy of religious modes of healing the market for them continues to grow. The Routledge Handbook of Religion Medicine and Health is an outstanding reference source to the key topics problems and debates in this exciting subject and is the first collection of its kind. Comprising over thirty-five chapters by a team of international contributors the Handbook is divided into five parts: Healing practices with religious roots and frames Religious actors in and around the medical field Organizing infrastructures of religion and medicine: pluralism and competition Boundary-making between religion and medicine Religion and epidemics Within these sections central issues debates and problems are examined including health and healing religiosity spirituality biomedicine medicalization complementary medicine medical therapy efficacy agency and the nexus of body mind and spirit. The Routledge Handbook of Religion Medicine and Health is essential reading for students and researchers in religious studies. The Handbook will also be very useful for those in related fields such as sociology anthropology and medicine.

GBP 205.00
1

Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors rare diseases orphan drugs the costs of drug development and therapies and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions carboxylesterase inhibitors for pharmaceutical applications employment of inhibitors for the treatment of neurodegenerative diseases use of engineered proteins bioactive peptides and fibrinolytic enzymes for thrombolytic therapy and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance computer-aided drug design for the identification of multi-target directed ligands and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs. | Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

GBP 193.00
1

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg) mesenchymal stromal/stem cells and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis chronic inflammatory demyelinating polyneuropathy neuromyelitis optica and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique cell collection and processing conditioning regimens infections and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications efficacy and regulatory oversight | Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

GBP 180.00
1

National Association of Broadcasters Engineering Handbook

National Association of Broadcasters Engineering Handbook

The NAB Engineering Handbook is the definitive resource for broadcast engineers. It provides in-depth information about each aspect of the broadcast chain from audio and video contribution through an entire broadcast facility all the way to the antenna. New topics include Ultra High Definition Television Internet Radio Interfacing and Streaming ATSC 3. 0 Digital Audio Compression Techniques Digital Television Audio Loudness Management and Video Format and Standards Conversion. Important updates have been made to incumbent topics such as AM Shortwave FM and Television Transmitting Systems Studio Lighting Cameras and Principles of Acoustics. The big-picture comprehensive nature of the NAB Engineering Handbook will appeal to all broadcast engineers—everyone from broadcast chief engineers who need expanded knowledge of all the specialized areas they encounter in the field to technologists in specialized fields like IT and RF who are interested in learning about unfamiliar topics. Chapters are written to be accessible and easy to understand by all levels of engineers and technicians. A wide range of related topics that engineers and technical managers need to understand are covered including broadcast documentation FCC practices technical standards security safety disaster planning facility planning project management and engineering management. | National Association of Broadcasters Engineering Handbook

GBP 200.00
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Scientific and Medical Knowledge Production 1796-1918 Experiment Expertise Experience

Scientific and Medical Knowledge Production 1796-1918 Experiment Expertise Experience

This collection pieces together a wealth of material in order to get inside the experience of scientific practice in the long nineteenth century. It aims to reach or perhaps to facilitate an understanding of the ways in which the value of scientific knowledge was produced lived and challenged. The new turn to the history of experience suggests a logic to the compilation of material that is completely original: the sources are not selected according to the historical success of an idea or experiment but for the ways in which scientific endeavour loaded knowledge claims with political or moral value coupled with attendant practical justifications. Thus ‘bad ideas’ sit alongside ‘good’; now discountenanced practices take their place among the revered. In sum they reveal an experimental culture that was not merely orientated toward cold knowledge or intellectual output but defined by shifting sets of affective practices and procedures and the making of expertise out of the lived experience of doing science. | Scientific and Medical Knowledge Production 1796-1918 Experiment Expertise Experience

GBP 396.00
1

Plumbing

Plumbing

Students setting out for a career in plumbing need a clear concise and comprehensive textbook to help them study for their Technical Certificate and Level 2 NVQ � and this book meets all those needs. Steve Muscroft expertly guides you through each of the key areas and processes in plumbing from the basics through cold and hot water systems to health and safety and best practice on site. The best way to learn something is to do it for yourself � so along with the theory this book is full of practical advice and guidance on how to get the job done. Every chapter is packed with colour photographs and diagrams to make learning easier. To help reinforce understanding each section features self-test exercises based on the standard City and Guilds assessment method. Steve Muscroft�s Plumbing isn�t just a guide to passing the exam � it goes into much more detail than other textbooks Extra material on key topics outside the core syllabus and references to additional resources and organisations make this book a handy companion as you begin your plumbing career. For the price of a spanner can you afford to be without it!

GBP 180.00
1

Comprehensive Aphasia Test

Comprehensive Aphasia Test

The Comprehensive Aphasia Test (CAT) is a test for use with people who have acquired aphasia that can be completed over one or two assessment sessions. The test includes a user manual a cognitive screen and language battery and a scoring booklet which are all unchanged since the previous edition and - new to this release - a concise Aphasia Impact Questionnaire which replaces the Disability Questionnaire. The cognitive section assesses people's abilities across a range of task that can affect rehabilitation. Forming the main body of the test the language battery provides a profile of performance across all modalities of language production and comprehension. The Aphasia Impact Questionnaire is a pictorial Patient Reported Outcome Measure which produces both qualitative and quantitative information. It was co-produced with people with aphasia. It supports the person with aphasia to give a subjective rating of how language difficulties identified in the Language Battery affect their daily life enabling first steps towards goal setting. By capturing this information the CAT helps the therapist track changes over the course of recovery and provides a guide to likely outcomes on the basis of an early assessment. The first two sections of the CAT are supported by normative data on people both with and without aphasia and extensive data on reliability and clinical validity. The CAT allows users to: Identify underlying impairments Find where to focus assessments using PALPA and other batteries Ascertain the practical psychological and social impact of aphasia from the perceptive of the person with aphasia Create a profile of strengths and weaknesses to guide therapy. Structured around fully up-to-date models of language assessment from cognitive neuropsychology to patient reported outcome measures test is an indispensable resource for speech and language therapists and researchers. It provides as much information about people's language ability as possible in a relatively brief test designed to be completed in 90-120 minutes. Additional scoring booklets can be ordered in packs of 10 at https://www. routledge. com/Comprehensive-Aphasia-Test-Scoring-Book-pack-of-10/Swinburn-Porter-Howard/p/book/ 9781032128177

GBP 250.00
1

Organelle and Molecular Targeting

Organelle and Molecular Targeting

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines such as the mRNA vaccines encoding the viral spike protein demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA DNA and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines reducing the required dose and therefore the biomanufacturing demand. Likewise improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies cancer neurodegeneration progerias diabetes and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status demand and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students scientists and clinicians contributing to modern medicine.

GBP 200.00
1

Animation: A World History The Complete Set

Animation: A World History The Complete Set

A continuation of 1994’s groundbreaking Cartoons Giannalberto Bendazzi’s three-volume Animation: A World History is the largest deepest most comprehensive text of its kind based on the idea that animation is an art form that deserves its own place in scholarship. Bendazzi delves beyond just Disney offering readers glimpses into the animation of Russia Africa Latin America and other often-neglected areas and introducing over fifty previously undiscovered artists. Full of first-hand never before investigated and elsewhere unavailable information Animation: A World History encompasses the history of animation production on every continent over the span of three centuries. Features include: Over 200 high quality head shots and film stills to add visual reference to your research Detailed information on hundreds of never-before researched animators and films Coverage of animation from more than 90 countries and every major region of the world Chronological and geographical organization for quick access to the information you’re looking for Volume I traces the roots and predecessors of modern animation the history behind Émile Cohl's Fantasmagorie and twenty years of silent animated films. Encompassing the formative years of the art form through its Golden Age this book accounts for animation history through 1950 and covers everything from well-known classics like Steamboat Willie to animation in Egypt and Nazi Germany. Volume II delves into the decades following the Golden Age an uncertain time when television series were overshadowing feature films art was heavily influenced by the Cold War and new technologies began to emerge that threatened the traditional methods of animation. Take part in the turmoil of the 1950s through 90s as American animation began to lose its momentum and the advent of television created a global interest in the art form. Volume III catches you up to speed on the state of animation from 1991 to present. Although characterized by such trends as economic globalization the expansion of television series emerging markets in countries like China and India and the consolidation of elitist auteur animation the story of contemporary animation is still open to interpretation. With an abundance of first-hand research and topics ranging from Nickelodeon and Pixar to modern Estonian animation this book is the most complete record of modern animation on the market. | Animation: A World History The Complete Set

GBP 350.00
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Biology and Biotechnology of Environmental Stress Tolerance in Plants 3-Volume Set

Biology and Biotechnology of Environmental Stress Tolerance in Plants 3-Volume Set

This new 3-volume set provides a comprehensive understanding of the mechanisms that mediate biosynthesis accumulation and degradation of plant metabolites so as to employ novel strategies to improve crop production and enhance abiotic stress tolerance in plants. Abiotic stresses such as drought high salt cold heat UV radiation heavy metal pollution etc. are increasingly responsible for restricting plant growth and agricultural production and are becoming more alarming due to threats from global climate change. To combat these threats it is imperative to study the underlying mechanisms of stress tolerance from diverse metabolites and the biosynthesis pathways for metabolite production to maintain osmotic balance under diverse environmental stresses. Biology and Biotechnology of Environmental Stress Tolerance in Plants provides that understanding. Volume 1: Secondary Metabolites in Environmental Stress Tolerance focuses exclusively on the diverse secondary metabolites that play a major role in the adaptation of plants to the environment and in overcoming stress conditions as well as their implications in enhancing tolerance mechanisms. The chapters in this section review and integrate the currently available information on the protective role rendered by a wide array of antioxidative secondary metabolites and their regulation during diverse environmental stress. Volume 2: Trace Elements in Environmental Stress Tolerance throws light on the different inorganic trace elements including metal nanoparticles that help to deal with various environmental stresses. While these elements at high level create considerable phytotoxicity and halt metabolic and enzymatic activity they also promote growth and development in limited quantity so that they have significant potential in revamping plant morphology and physiology under stressed conditions. Hence optimum concentration management of these elements can help to mitigate world hunger and contribute toward sustainable agriculture and food security under challenging environments. Volume 3: Sustainable Approaches for Enhancing Environmental Stress Tolerance focuses on the agronomic and biochemical approaches as well as biotechnological and high-throughput technologies including the prospects of genetic engineering epigenetics and the latest CRISPR/Cas technology in generating stress-tolerant plants. The volume provides a clear road map for the implementation of techniques for improving abiotic stress tolerance in plants for better sustenance. Key features: Provides an advanced understanding of the mechanisms of action of secondary metabolites and trace elements in environmental stress tolerance as well as the different agronomic and biotechnological methods that enhances stress tolerance Looks at the overall metabolic pathways and genetic engineering giving a holistic view of plant-level studies of diverse abiotic stresses affecting different metabolic pathways Provides the groundwork to help researchers in designing future programs for identifying novel genes and proteins and targeting proper pathways to develop climate-resilient plants Altogether the three-volume Biology and Biotechnology of Environmental Stress Tolerance in Plants will enhance our understanding of plant responses to environmental stresses and enable implementation of programs and practices that can help us to develop climate-resilient plants with better performance for better yield and quality. | Biology and Biotechnology of Environmental Stress Tolerance in Plants 3-Volume Set

GBP 437.00
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