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Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg) mesenchymal stromal/stem cells and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis chronic inflammatory demyelinating polyneuropathy neuromyelitis optica and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique cell collection and processing conditioning regimens infections and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications efficacy and regulatory oversight | Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

GBP 180.00
1

Tissue Type Plasminogen Activity Volume I

Tissue Type Plasminogen Activity Volume I

This book is made possible by the enthusiastic contributions of the authors of the chapters. They have been invited from young and active scientists in the field of t-PA research. I am grateful for their contribution and for the fact that all accepted the specifications of their chapter in order to obtain a structured book. Inevitably some overlap does exist; on the one hand to enable controversial or unsettled areas to be discussed by the different experts with a different approach and background. It is a particular pleasure and honor that Dr. T. Astrup as an eye-witness and essential contributor to the history of t-PA discovery and research gives a unique account of the history of t-PA research in the first chapter of the book. | Tissue Type Plasminogen Activity Volume I

GBP 200.00
1

Handbook for Death Scene Investigators

Handbook for Death Scene Investigators

Handbook for Death Scene Investigators provides concise information in a handy pocket-sized (3 1/2 x 6) format - perfect for on-the-scene reference. Details about sudden natural deaths by disease and accidents are emphasized in this guidebook complemented with practical information on:reviewing a medical chartcollecting evidenceobtaining a medical historyinteracting with other law enforcement personnel witnesses and relativesAnyone responsible for investigating natural deaths - from police investigators to medical examiners - can go direct to the information they need at a moment's notice with the Handbook for Death Scene InvestigatorsFeatures

GBP 190.00
1

Principles of Horticulture: Level 2

Principles of Horticulture: Level 2

This colourful guide will introduce you to the fundamentals of horticulture whether you are taking a Level 2 RHS City and Guilds or BTEC course are a keen amateur or seasoned gardener. Written in a clear and accessible style this book covers the principles that underpin growing plants for the garden and on the allotment with reference to how these are tackled by professionals. With highlighted definitions key points and illustrated in full colour this book will be a useful companion as you progress in the study and practice of horticulture. Complete with a companion website which includes extended horticultural information questions and exercises to test your knowledge syllabus cross-referencing and downloadable tutor and student support materials. Available at www. routledge. com/cw/adams | Principles of Horticulture: Level 2

GBP 180.00
1

Sustainable Horticulture 2 Volume Set

Sustainable Horticulture 2 Volume Set

This timely two-volume compendium Sustainable Horticulture addresses the most important topics facing horticulture around the world today. The volumes cover a wide range of topical issues and trends in sustainable horticulture today: Volume 1: Diversity Production and Crop Improvements and Volume 2: Food Health and Nutrition. Global food demand is expected to be double by 2050 while at the same time the production environment and natural resources are continually shrinking and deteriorating due to many complex factors. Horticulture a major sector of agriculture is vital to enhancing crop production and productivity in parity with agricultural crops to meet the emerging food demand. Implementing sustainable models of crop production is really an enormous endeavor. Promising technologies and management options are needed to increase productivity to meet the growing food demand despite deteriorating production environments. | Sustainable Horticulture 2 Volume Set

GBP 231.00
1

Textbook of Assisted Reproductive Techniques Volume 2: Clinical Perspectives

Textbook of Assisted Reproductive Techniques Volume 2: Clinical Perspectives

Established as the definitive reference for the IVF clinic the sixth edition has been extensively revised with the addition of several important new contributions on clinical topics including The use of digitalization and precision medicine in the IVF clinic The environment and reproduction The use of gonadotropin-releasing hormone agonists and the efficiency of IVF Controlled ovarian stimulation for freeze-all cycles Immunology in ART Home monitoring of ART cycles Luteal-phase support in ART The POSEIDON stratification of ‘low prognosis’ patients in ART Controlled ovarian stimulation for low responder patients Adjuvants for poor responders Innovative therapies in diminished ovarian reserve and primary ovarian insufficiency patients and Fertility options for transgender and nonbinary individuals. As previously methods protocols and techniques of choice are presented by IVF pioneers and eminent international experts. | Textbook of Assisted Reproductive Techniques Volume 2: Clinical Perspectives

GBP 200.00
1

Phytochemical Composition and Pharmacy of Medicinal Plants 2-volume set

Phytochemical Composition and Pharmacy of Medicinal Plants 2-volume set

This new 2-volume set offers a comprehensive review of more than 80 medicinal plant species providing information on the bioactives and pharmacology of these beneficial plants. It describes the structures of the secondary metabolites found in these plants the functions of these compounds in human and plant biology and the biosynthesis of these compounds. Each chapter begins with a brief introduction about the species. The chapters then delve into the bioactive phytochemicals from the plant along with its chemical structure. The published literature on pharmacological activities on that species is comprehensively reviewed. A wide array of the biological activities and potential health benefits of the medicinal plant (which include antiviral antimicrobial antioxidant anti-cancer anti-inflammatory and antidiabetic properties as well as protective effects on liver kidney heart and nervous system) are given. Phytochemical Composition and Pharmacy of Medicinal Plants aims to be valuable source book for scientists researchers industry professionals faculty and students for the development of new and effective drugs from medicinal plants. | Phytochemical Composition and Pharmacy of Medicinal Plants 2-volume set

GBP 308.00
1

Advances in Audiology and Hearing Science (2-volume set) Volume 1: Clinical Protocols and Hearing Devices Volume 2: Otoprotection Regenera

Advances in Audiology and Hearing Science (2-volume set) Volume 1: Clinical Protocols and Hearing Devices Volume 2: Otoprotection Regenera

With chapters from audiology professionals from around the world Advances in Audiology and Hearing Science-presented in two volumes—provides an abundance of valuable information on the latest technological and procedural advances in this ever-improving field. Volume 1 primarily focuses on revised clinical protocols and provides information on new research to help guide decisions and criteria regarding diagnosis management and treatment of hearing-related issues. Topics include new clinical applications such as auditory steady-state response wideband acoustic immittance otoacoustic emissions frequency following response noise exposure genomics and hearing loss and more. Volume 2 includes sections with material related to hearing devices hearing in special populations such as the children and the elderly as well chapters on the fast-growing subfields of otoprotection and regeneration including pharmacologic otoprotection stem cells and nanotechnology. Topics include early auditory development in children after cochlear implantation music therapy the effect of music on hearing health and auditory enhancement. | Advances in Audiology and Hearing Science (2-volume set) Volume 1: Clinical Protocols and Hearing Devices Volume 2: Otoprotection Regenera

GBP 308.00
1

Organelle and Molecular Targeting

Organelle and Molecular Targeting

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines such as the mRNA vaccines encoding the viral spike protein demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA DNA and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines reducing the required dose and therefore the biomanufacturing demand. Likewise improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies cancer neurodegeneration progerias diabetes and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status demand and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students scientists and clinicians contributing to modern medicine.

GBP 200.00
1

Spaces for the Future A Companion to Philosophy of Technology

Spaces for the Future A Companion to Philosophy of Technology

Focused on mapping out contemporary and future domains in philosophy of technology this volume serves as an excellent forward-looking resource in the field and in cognate areas of study. The 32 chapters all of them appearing in print here for the first time were written by both established scholars and fresh voices. They cover topics ranging from data discrimination and engineering design to art and technology space junk and beyond. Spaces for the Future: A Companion to Philosophy of Technology is structured in six parts: (1) Ethical Space and Experience; (2) Political Space and Agency; (3) Virtual Space and Property; (4) Personal Space and Design; (5) Inner Space and Environment; and (6) Outer Space and Imagination. The organization maps out current and emerging spaces of activity in the field and anticipates the big issues that we soon will face. | Spaces for the Future A Companion to Philosophy of Technology

GBP 205.00
1

MoCap for Artists Workflow and Techniques for Motion Capture

MoCap for Artists Workflow and Techniques for Motion Capture

Make motion capture part of your graphics and effects arsenal. This introduction to motion capture principles and techniques delivers a working understanding of today's state-of-the-art systems and workflows without the arcane pseudocodes and equations. Learn about the alternative systems how they have evolved and how they are typically used as well as tried-and-true workflows that you can put to work for optimal effect. Demo files and tutorials provided on the downloadable resources deliver first-hand experience with some of the core processes. | MoCap for Artists Workflow and Techniques for Motion Capture

GBP 180.00
1

Eleventh International Conference on the Bearing Capacity of Roads Railways and Airfields Volume 2

Eleventh International Conference on the Bearing Capacity of Roads Railways and Airfields Volume 2

Innovations in Road Railway and Airfield Bearing Capacity – Volume 2 comprises the second part of contributions to the 11th International Conference on Bearing Capacity of Roads Railways and Airfields (2022). In anticipation of the event it unveils state-of-the-art information and research on the latest policies traffic loading measurements in-situ measurements and condition surveys functional testing deflection measurement evaluation structural performance prediction for pavements and tracks new construction and rehabilitation design systems frost affected areas drainage and environmental effects reinforcement traditional and recycled materials full scale testing and on case histories of road railways and airfields. This edited work is intended for a global audience of road railway and airfield engineers researchers and consultants as well as building and maintenance companies looking to further upgrade their practices in the field. | Eleventh International Conference on the Bearing Capacity of Roads Railways and Airfields Volume 2

GBP 180.00
1

Optics for Engineers

Optics for Engineers

The field of optics has become central to major developments in medical imaging remote sensing communication micro- and nanofabrication and consumer technology among other areas. Applications of optics are now found in products such as laser printers bar-code scanners and even mobile phones. There is a growing need for engineers to understand the principles of optics in order to develop new instruments and improve existing optical instrumentation. Based on a graduate course taught at Northeastern University Optics for Engineers provides a rigorous practical introduction to the field of optics. Drawing on his experience in industry the author presents the fundamentals of optics related to the problems encountered by engineers and researchers in designing and analyzing optical systems. Beginning with a history of optics the book introduces Maxwell‘s equations the wave equation and the eikonal equation which form the mathematical basis of the field of optics. It then leads readers through a discussion of geometric optics that is essential to most optics projects. The book also lays out the fundamentals of physical optics polarization interference and diffraction in sufficient depth to enable readers to solve many realistic problems. It continues the discussion of diffraction with some closed-form expressions for the important case of Gaussian beams. A chapter on coherence guides readers in understanding the applicability of the results in previous chapters and sets the stage for an exploration of Fourier optics. Addressing the importance of the measurement and quantification of light in determining the performance limits of optical systems the book then covers radiometry photometry and optical detection. It also introduces nonlinear optics. This comprehensive reference includes downloadable MATLAB code as well as numerous problems examples and illustrations. An introductory text for

GBP 180.00
1

Scenic Art for the Theatre

Scenic Art for the Theatre

Now in its Third Edition Scenic Art for the Theatre: History Tools and Techniques continues to be the most trusted source for both student and professional scenic artists. With new information on scenic design using Photoshop Paint Shop Pro and other digital imaging softwares this test expands to offer the developing artist more step-by-step instuction and more practical techniques for work in the field. It goes beyond detailing job functions and discussing techniques to serve as a trouble-shooting guide for the scenic artist providing practical advice for everyday solutions.

GBP 180.00
1

Handbook for History Teachers

Handbook for History Teachers

First published in 1972 Handbook for History Teachers is intended to be a general and comprehensive work of reference for teachers of history in primary and secondary schools of all kinds. The book covers all aspects of teaching history: among them are the use of sources world history art and history; principles of constructing a syllabus and the psychological aspects of history teaching. The bibliographical sections are arranged on three parts: school textbooks a section on audio-visual-aids and finally books for the teacher and possibly for the sixth form. It thoroughly investigates and critiques the various methods employed in teaching history within classrooms and suggests alternatives wherever applicable. Diligently curated by the Standing Sub-Committee in History University of London Institute of Education the book still holds immense value in the understanding of pedagogy.

GBP 230.00
1

Problem Solving for Engineers

Problem Solving for Engineers

Whatever their discipline engineers are routinely called upon to develop solutions to all kinds of problems. To do so effectively they need a systematic and disciplined approach that considers a range of alternatives taking into account all relevant factors before selecting the best solution. In Problem Solving for Engineers David Carmichael demonstrates just such an approach involving problem definition generation of alternative solutions and ultimately the analysis and selection of a preferred solution. David Carmichael introduces the fundamental concepts needed to think systematically and undertake methodical problem solving. He argues that the most rational way to develop a framework for problem solving is by using a systems studies viewpoint. He then outlines systems methodology modeling and the various configurations for analysis synthesis and investigation. Building on this the book details a systematic process for problem solving and demonstrates how problem solving and decision making lie within a systems synthesis configuration. Carefully designed as a self-learning resource the book contains exercises throughout that reinforce the material and encourage readers to think and apply the concepts. It covers decision making in the presence of uncertainty and multiple criteria including that involving sustainability with its blend of economic social and environmental considerations. It also characterizes and tackles the specific problem solving of management planning and design. The book provides for the first time a rational framework for problem solving with an engineering orientation.

GBP 180.00
1

Machining Technology and Operations 2-Volume Set

Machining Technology and Operations 2-Volume Set

This two-volume set addresses both current and developing topics of advanced machining technologies and machine tools used in industry. The treatments are aimed at motiving and challenging the reader to explore viable solutions to a variety of questions regarding product design and optimum selection of machining operations for a given task. This two-volume set will be useful to professionals students and companies in the areas of mechanical industrial manufacturing materials and production engineering fields. Traditional Machining Technology covers the technologies machine tools and operations of traditional machining processes. These include the general-purpose machine tools used for turning drilling and reaming shaping and planing milling grinding and finishing operations. Thread and gear cutting and broaching processes are included along with semi-automatic automatic NC and CNC machine tools operations tooling mechanisms accessories jigs and fixtures and machine tool dynamometry are discussed. Non-Traditional and Advanced Machining Technologies covers the technologies machine tools and operations of non-traditional mechanical chemical and thermal machining processes. Assisted machining technologies machining of difficult-to-cut materials design for machining accuracy and surface integrity of machined parts environment-friendly machine tools and operations and hexapods are also presented. The topics covered throughout this volume reflect the rapid and significant advances that have occurred in various areas in machining technologies. | Machining Technology and Operations 2-Volume Set

GBP 290.00
1

Advanced Technologies for Meat Processing

Advanced Technologies for Meat Processing

As with the first edition the main goal of Advanced Technologies for Meat Processing is to provide the reader with recent developments in new advanced technologies for the full meat- processing chain. This book is written by distinguished international contributors with recognized expertise and excellent reputations and brings together all the advances in a wide and varied number of technologies that are applied in different stages of meat processing. This second edition contains 21 chapters combining updated and revised versions of several chapters with entirely new chapters that deal with new online monitoring techniques like hyperspectral imaging and Raman spectroscopy the use of nanotechnology for sensor devices or new packaging materials and the application of omics technologies like nutrigenomics and proteomics for meat quality and nutrition. The book starts with the control and traceability of genetically modified farm animals followed by four chapters reporting the use of online non-destructive monitoring techniques like hyperspectral imaging and Raman spectroscopy real-time PCR for pathogens detection and nanotechnology-based sensors. Then five chapters describe different advanced technologies for meat decontamination such as irradiation hydrostatic and hydrodynamic pressure processing other non-thermal technologies and the reduction in contaminants generation. Nutrigenomics in animal nutrition and production is the object of a chapter that is followed by five chapters dealing with nutritional-related issues like bioactive peptides functional meats fat and salt reduction processing of nitrite-free products and the use of proteomics for the improved processing of dry-cured meats. The last four chapters are reporting the latest developments in bacteriocins against meat-borne pathogens the functionality of bacterial starters modified atmosphere packaging and the use of new nanotechnology-based materials for intelligent and edible packaging.

GBP 180.00
1

Introduction to Market Access for Pharmaceuticals

Introduction to Market Access for Pharmaceuticals

Market access is the fourth hurdle in the drug development process and the primary driver for global income of any new drug. Without a strategy in place for pricing showing value for effectiveness and an understanding of the target purchasers needs the drug will fail to reach its intended market value. Introduction to Market Access for Pharmaceuticals is based on an accredited course in this area taken from the European Market Access University Diploma (EMAUD) and is affiliated with Aix Marseille University.

GBP 180.00
1

Pixel Art for Game Developers

Pixel Art for Game Developers

Is the art for your video game taking too long to create? Learning to create Pixel Art may be the answer to your development troubles. Uncover the secrets to creating stunning graphics with Pixel Art for Game Developers. The premier how-to book on Pixel Art and Pixel Art software it focuses on the universal principles of the craft. The book provides an introduction to Pixel Art its utility foundational elements and concepts such as light and shadow. It offers tutorials on creating animations and serves as a functional guide for the most common methodology in 2D game development. Gamers love the retro feel of Pixel Art and lucky for you it is easy to create. You'll love the tiny file sizes that will reduce compile times and help your game run faster. Providing you with the skills to create the characters and environments needed for 2D games this book will help you: Create tilesets to build game environments Understand light and shadow Work efficiently with pixels Use atmospheric and linear perspective Create professional-quality Pixel Art This book has chapters dedicated to theory as well as step-by-step tutorials both of which describe the process explicitly. Whether you are an artist programmer indie developer or certified public accountant after reading this book you'll understand the steps necessary to create production-quality Pixel Art graphics. Praise for the Book:Pixel Art and Pixel Art games are very popular and the technique is a great way for independent creators to create very good-looking games with limited resources. It‘s frankly shocking that there hasn‘t been a resource like this before . a very timely book. Chris Totten George Mason University Washington DC USA

GBP 180.00
1

Routledge Handbook for Creative Futures

Routledge Handbook for Creative Futures

As the uncertainty of global and local contexts continues to amplify the Routledge Handbook for Creative Futures responds to the increasing urgency for reimagining futures beyond dystopias and utopias. It features essays that explore the challenges of how to think about compelling futures what these better futures might be like and what personal and collective practices are emerging that support the creation of more desirable futures. The handbook aims to find a sweet spot somewhere between despair and naïve optimism neither shying away from the massive socio-environmental planetary challenges currently facing humanity nor offering simplistic feel-good solutions. Instead it offers ways forward—whether entirely new perspectives or Indigenous and Traditional Knowledge perspectives that have been marginalized within modernity—and shares potential transformative practices. The volume contains contributions from established and emerging scholars practitioners and scholar-practitioners with diverse backgrounds and experiences: a mix of Indigenous Black Asian and White/Caucasian contributors including women men and trans people from around the world in places such as Kenya India US Canada and Switzerland among many others. Chapters explore critical concepts alongside personal and collective practices for creating desirable futures at the individual community organizational and societal levels. This scholarly and accessible book will be a valuable resource for researchers and students of leadership studies social innovation community and organizational development policy studies futures studies cultural studies sociology and management studies. It will also appeal to educators practitioners professionals and policymakers oriented toward activating creative potential for life-affirming futures for all.

GBP 190.00
1

Graphical Methods for Data Analysis

Graphical Methods for Data Analysis

This book present graphical methods for analysing data. Some methods are new and some are old some require a computer and others only paper and pencil; but they are all powerful data analysis tools. In many situations a set of data � even a large set- can be adequately analysed through graphical methods alone. In most other situations a few well-chosen graphical displays can significantly enhance numerical statistical analyses. | Graphical Methods for Data Analysis

GBP 205.00
1

A Geology for Engineers

A Geology for Engineers

No engineering structure can be built on the ground or within it without the influence of geology being experienced by the engineer. Yet geology is an ancillary subject to students of engineering and it is therefore essential that their training is supported by a concise reliable and usable text on geology and its relationship to engineering. In this book all the fundamental aspects of geology are described and explained but within the limits thought suitable for engineers. It describes the structure of the earth and the operation of its internal processes together with the geological processes that shape the earth and produce its rocks and soils. It also details the commonly occurring types of rock and soil and many types of geological structure and geological maps. Care has been taken to focus on the relationship between geology and geomechanics so emphasis has been placed on the geological processes that bear directly upon the composition structure and mechanics of soil and rocks and on the movement of groundwater. The descriptions of geological processes and their products are used as the basis for explaining why it is important to investigate the ground and to show how the investigations may be conducted at ground level and underground. Specific instruction is provided on the relationship between geology and many common activities undertaken when engineering in rock and soil. | A Geology for Engineers

GBP 180.00
1

Instrumentation for Trace Organic Monitoring

Instrumentation for Trace Organic Monitoring

Instrumentation for Trace Organic Monitoring provides comprehensive coverage of instrumental analysis techniques for trace organic analytes in environmental analysis. Sampling/sample preparation is discussed in addition to mass spectrometry techniques including GC-MS HRMS LCMS APIMS and MS-MS. This important book also covers new chromatography techniques supercritical fluid solid-phase extraction and ion mobility spectrometry which is a new ultra-sensitive technique. Difficult problems such as dioxin/furan analysis organometallic speciation atmospheric organic vapors water analysis and flyash toxicity testing are addressed.

GBP 205.00
1